Al-Saadi Rose S, Phillips Patrick C
Institute of Ecology & Evolution, University of Oregon, Eugene, Oregon, 97403, USA.
bioRxiv. 2025 Jul 2:2025.06.29.662228. doi: 10.1101/2025.06.29.662228.
Sex differences in aging are robust and ubiquitous. Demographic differences in aging generated by sex have long been recognized, but the underlying biological basis for these differences and the potential for sex-specific interventions remain understudied. To explore sex differences in the response to pro-longevity interventions, we utilized the aging model and asked whether male lifespan and reproductive healthspan can be extended via compounds known to have pro-longevity effects in hermaphrodites. We tested seven different compounds at two concentrations each and found that lifespan was extended under all tested conditions. However, reproductive healthspan measured by mating success in late life improved under only two tested conditions, sulforaphane and metformin. These results demonstrate that lifespan and healthspan can be decoupled in males and offer a new framework for screening pro-longevity compounds and for studying sex differences in aging in a classical aging model.
衰老过程中的性别差异是显著且普遍存在的。性别导致的衰老在人口统计学上的差异早已为人所知，但这些差异背后的生物学基础以及针对性别的干预潜力仍未得到充分研究。为了探究对延长寿命干预措施的反应中的性别差异，我们利用了衰老模型，并询问雄性的寿命和生殖健康寿命是否可以通过已知对雌雄同体具有延长寿命作用的化合物来延长。我们在两种浓度下测试了七种不同的化合物，发现所有测试条件下寿命都得到了延长。然而，通过晚年交配成功率衡量的生殖健康寿命仅在两种测试条件下有所改善，即萝卜硫素和二甲双胍。这些结果表明，雄性的寿命和健康寿命可以脱钩，并为筛选延长寿命的化合物以及在经典衰老模型中研究衰老过程中的性别差异提供了一个新的框架。
