Gummer C L, Dawber R P
Br J Dermatol. 1985 Sep;113(3):273-80. doi: 10.1111/j.1365-2133.1985.tb02078.x.
We have used detailed ultrastructural and electron histochemical techniques on both the hair shaft and anagen hair follicle to elucidate further the structural abnormalities in trichothiodystrophic hair. We have shown that protein deposition in the follicle is reduced and lacks orientation, and that the anagen follicles show an overall distortion. Both the hair cuticle and cortex high sulphur protein components are affected. The results of this study help to give a visual interpretation to detailed biochemical studies conducted by other workers thereby allowing specific localization of the site of the intrinsic keratin abnormality.
我们运用了详细的超微结构和电子组织化学技术，对毛干和生长期毛囊进行研究，以进一步阐明毛发硫营养不良症毛发的结构异常。我们已经表明，毛囊中的蛋白质沉积减少且缺乏定向性，并且生长期毛囊呈现出整体扭曲。毛小皮和皮质高硫蛋白成分均受到影响。这项研究的结果有助于对其他研究人员进行的详细生化研究给出直观解释，从而实现对内在角蛋白异常部位的特异性定位。
