Lynch H T, Fusaro R M, Roberts L, Voorhees G J, Lynch J F
Br J Dermatol. 1985 Sep;113(3):295-301. doi: 10.1111/j.1365-2133.1985.tb02081.x.
Distinguishing cutaneous signs which are associated with hereditary cancer-prone syndromes are known as cancer-associated genodermatoses. Muir-Torre syndrome (M-T) is characterized by the occurrence of sebaceous hyperplasia, adenoma and carcinoma, basal cell carcinoma with sebaceous differentiation, and/or keratoacanthoma in association with visceral cancer (often multiple), and improved survival. Family studies of M-T have been either wholly lacking or too incomplete to elucidate hereditary aetiology. We describe the cutaneous phenotype of M-T in an extended kindred with a possible variant of the Cancer Family Syndrome. We emphasize the need for more thorough documentation of family histories and cancer association in this cancer-associated genodermatosis in order to clarify hereditary syndrome identification, and to improve cancer control through employment of cutaneous signs as a beacon for highly targeted forms of visceral cancer.
与遗传性易患癌综合征相关的可识别皮肤体征被称为癌症相关遗传性皮肤病。穆尔-托雷综合征（M-T）的特征是出现皮脂腺增生、腺瘤和癌、具有皮脂腺分化的基底细胞癌，和/或伴有内脏癌（通常为多发）的角化棘皮瘤，以及生存率提高。关于M-T的家族研究要么完全缺失，要么过于不完整，无法阐明遗传病因。我们描述了一个可能为癌症家族综合征变体的大家族中M-T的皮肤表型。我们强调，对于这种癌症相关遗传性皮肤病，需要更全面地记录家族病史和癌症关联，以便明确遗传性综合征的识别，并通过将皮肤体征作为高度靶向性内脏癌的信号，来改善癌症防控。
