Eid Alaa Youssef, Al-Mahdy Dalia A, Sayed Rabab H, Choucry Mouchira A, El-Askary Hesham
Department of Pharmacognosy, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Indian J Pharmacol. 2025 May 1;57(3):134-144. doi: 10.4103/ijp.ijp_636_24. Epub 2025 Jul 9.
Alopecia, a common condition causing hair loss, leads to decreased self-esteem worldwide. Natural extracts such as rosemary (Rosmarinus officinalis L.) and capsicum (Capsicum annuum L.), traditionally used for various medicinal purposes in Egypt, are widely utilized in treatments for androgenetic alopecia and hair care products. However, these extracts lack market standardization and clear specifications, leading to inconsistent and unpredictable effects.
This study aims to investigate the effects of standardized rosemary and capsicum extracts on testosterone-induced androgenetic alopecia in rats to ensure consistent quality and safety in marketed hair care products.
The study involved preparing standardized rosemary and capsicum extracts and developing simple, accurate, sensitive, rapid, and reproducible methods for both. The extracts were tested on adult male Wistar rats with testosterone-induced alopecia, using a 2% finasteride solution as a reference standard. Visual and microscopic evaluations were conducted to measure three hair follicle parameters: diameter, length, and density.
This study demonstrated the potent effects of standardized rosemary and capsicum extracts on hair growth parameters over 21 days; the application of 0.075% of standardized capsicum extract significantly improved hair growth parameters, including follicle density, length, and diameter. Furthermore, standardized rosemary extracts at 3% and 5% concentrations showed significant improvements across all measured parameters, particularly in hair follicle density.
This study highlights the potential of standardized rosemary and capsicum extracts in promoting hair growth parameters, including hair follicle density, length, and diameter. It will pave the way for more effective natural-based androgenetic alopecia treatment.
脱发是一种导致头发脱落的常见病症，在全球范围内都会导致自尊心下降。迷迭香（Rosmarinus officinalis L.）和辣椒（Capsicum annuum L.）等天然提取物在埃及传统上用于各种药用目的，被广泛用于雄激素性脱发的治疗和护发产品中。然而，这些提取物缺乏市场标准化和明确的规格，导致效果不一致且不可预测。
本研究旨在调查标准化迷迭香和辣椒提取物对睾酮诱导的大鼠雄激素性脱发的影响，以确保市售护发产品的质量和安全性一致。
该研究包括制备标准化迷迭香和辣椒提取物，并开发简单、准确、灵敏、快速且可重复的方法。将提取物应用于睾酮诱导脱发的成年雄性Wistar大鼠，使用2%非那雄胺溶液作为参考标准。进行视觉和显微镜评估以测量三个毛囊参数：直径、长度和密度。
本研究证明了标准化迷迭香和辣椒提取物在21天内对毛发生长参数有显著影响；应用0.075%的标准化辣椒提取物可显著改善毛发生长参数，包括毛囊密度、长度和直径。此外浓度为3%和5%的标准化迷迭香提取物在所有测量参数上均有显著改善，尤其是在毛囊密度方面。
本研究突出了标准化迷迭香和辣椒提取物在促进毛发生长参数（包括毛囊密度、长度和直径）方面的潜力。它将为更有效的基于天然成分的雄激素性脱发治疗铺平道路。
