Ginsburg J, O'Reilly B, Swinhoe J
Br J Obstet Gynaecol. 1985 Nov;92(11):1169-75. doi: 10.1111/j.1471-0528.1985.tb03032.x.
The effect of an alpha-adrenergic agonist, clonidine hydrochloride, on cardiovascular responses to noradrenaline, adrenaline and angiotensin was investigated in menopausal women with hot flushes. The increase in forearm blood flow induced by adrenaline, noradrenaline or angiotensin was significantly less in women treated for at least 6 weeks with clonidine compared with that induced in the women by infusions given before treatment. Pulse rate during the amine infusions was significantly lower after clonidine treatment but constrictor responses in the hand were unchanged. These findings cannot be wholly explained in terms of an action of clonidine confined to adrenergic mechanisms and suggest that the drug may influence peripheral vascular responsiveness. Such an effect could explain the mechanism of the beneficial clinical action of the drug in subjects with menopausal flushing or migraine.
在患有潮热的绝经后女性中，研究了α-肾上腺素能激动剂盐酸可乐定对去甲肾上腺素、肾上腺素和血管紧张素引起的心血管反应的影响。与治疗前输注时相比，用可乐定治疗至少6周的女性，由肾上腺素、去甲肾上腺素或血管紧张素诱导的前臂血流量增加明显较少。可乐定治疗后，胺输注期间的脉搏率显著降低，但手部的收缩反应未改变。这些发现不能完全用可乐定局限于肾上腺素能机制的作用来解释，提示该药物可能影响外周血管反应性。这种作用可以解释该药物在绝经潮热或偏头痛患者中有益临床作用的机制。
