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TNF-α Pathway Activation and Altered microRNA Expression in Peripheral Blood-Derived Endothelial Colony-Forming Cells: Insights into Diabetes-Induced Dysfunction.

作者信息

Liu Yaqiong, Lyons Caomhán J, Keane Alan, McKeown Stuart, Pedrini Edoardo, Creane Michael, Soomro Nadeem, Straszewicz Alicja, Griffin Tomás, Stitt Alan, O'Brien Timothy

机构信息

Regenerative Medicine Institute, University of Galway, Galway, Ireland.

Wellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast, Belfast, UK.

出版信息

Stem Cell Rev Rep. 2025 Jul 9. doi: 10.1007/s12015-025-10908-6.

DOI:10.1007/s12015-025-10908-6
PMID:40632376
Abstract
摘要

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本文引用的文献

1
Role of miR-15a-5p and miR-199a-3p in the inflammatory pathway regulated by NF-κB in experimental and human atherosclerosis.miR-15a-5p 和 miR-199a-3p 在 NF-κB 调控的实验性和人类动脉粥样硬化炎症通路中的作用。
Clin Transl Med. 2023 Aug;13(8):e1363. doi: 10.1002/ctm2.1363.
2
MicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye.微小 RNA-146a 通过 IRAK1/TRAF6/NF-κB 信号通路负调控干眼的炎症反应。
Sci Rep. 2023 Jul 11;13(1):11192. doi: 10.1038/s41598-023-38367-4.
3
miR-146a-5p regulates autophagy and NLRP3 inflammasome activation in epithelial barrier damage in the in vitro cell model of ulcerative colitis through the RNF8/Notch1/mTORC1 pathway.
miR-146a-5p 通过 RNF8/Notch1/mTORC1 通路调控溃疡性结肠炎体外细胞模型中上皮屏障损伤的自噬和 NLRP3 炎性体激活。
Immunobiology. 2023 Jul;228(4):152386. doi: 10.1016/j.imbio.2023.152386. Epub 2023 Apr 14.
4
Plasma Exosomal miR-199a-5p Derived from Preeclampsia with Severe Features Impairs Endothelial Cell Function via Targeting SIRT1.重度子痫前期患者血浆来源的外泌体miR-199a-5p通过靶向SIRT1损害内皮细胞功能。
Reprod Sci. 2022 Dec;29(12):3413-3424. doi: 10.1007/s43032-022-00977-0. Epub 2022 Sep 7.
5
Functional Impairment of Endothelial Colony Forming Cells (ECFC) in Patients with Severe Atherosclerotic Cardiovascular Disease (ASCVD).严重动脉粥样硬化性心血管疾病（ASCVD）患者内皮祖细胞（ECFC）功能障碍。
Int J Mol Sci. 2022 Aug 11;23(16):8969. doi: 10.3390/ijms23168969.
6
Endothelial miR-199a-3p regulating cell adhesion molecules by targeting mTOR signaling during inflammation.炎症中内皮细胞 miR-199a-3p 通过靶向 mTOR 信号调节细胞黏附分子。
Eur J Pharmacol. 2022 Jun 15;925:174984. doi: 10.1016/j.ejphar.2022.174984. Epub 2022 Apr 28.
7
Inflammation in obesity, diabetes, and related disorders.肥胖、糖尿病及相关紊乱中的炎症。
Immunity. 2022 Jan 11;55(1):31-55. doi: 10.1016/j.immuni.2021.12.013.
8
MicroRNAs and their delivery in diabetic fibrosis.微小 RNA 及其在糖尿病纤维化中的传递。
Adv Drug Deliv Rev. 2022 Mar;182:114045. doi: 10.1016/j.addr.2021.114045. Epub 2021 Nov 9.
9
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases.miR-21 和 miR-146a：炎症衰老和与年龄相关疾病的 microRNAs。
Ageing Res Rev. 2021 Sep;70:101374. doi: 10.1016/j.arr.2021.101374. Epub 2021 May 31.
10
MiR-146a-5p promotes IL-1β-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway.miR-146a-5p 通过 TRAF6 介导的 NF-κB 通路促进 IL-1β 诱导的软骨细胞凋亡。
Inflamm Res. 2020 Jun;69(6):619-630. doi: 10.1007/s00011-020-01346-w. Epub 2020 Apr 23.