Izaguirre-Hernández Irma Yadira, Sumoza-Toledo Adriana
Facultad de Bioanálisis, Universidad Veracruzana. Agustín de Iturbide s/n esq. Carmen Serdán, Veracruz, Ver., 91700, México.
Instituto de Investigaciones Médico Biológicas, Universidad Veracruzana, Agustín de Iturbide S/N, Veracruz 91700, México.
J Leukoc Biol. 2025 Jul 9;117(7). doi: 10.1093/jleuko/qiaf098.
The tumor microenvironment (TME) is a complex and dynamic ecosystem consisting of both cellular and non-cellular components that collectively modulate the antitumor immune response, as well as cancer growth, invasion, metastasis, immune evasion, and resistance to therapy. Calcium (Ca2+) and magnesium (Mg2+) are two essential ions for a wide range of cellular processes, including proliferation, differentiation, migration, and protein secretion. The intracellular homeostasis and spatiotemporal distribution of these two ions are tightly regulated by ion channels, notably members of the transient receptor potential melastatin (TRPM) subfamily, such as TRPM2 and TRPM7. TRPM2 is a Ca2+-permeable channel activated by ADP-ribose (ADPR) and reactive oxygen species (ROS), whereas TRPM7 permeates both Ca2+ and Mg2+ ions and exhibits constitutive activity. Both channels have been involved in redox-sensitive signaling and function as temperature sensors across various physiological and pathological contexts, such as cancer. Here, we provide an overview of the potential roles of TRPM2 and TRPM7 in regulating cellular dynamics within the TME, with a focus on their contributions to immune modulation.
肿瘤微环境（TME）是一个复杂且动态的生态系统，由细胞和非细胞成分组成，这些成分共同调节抗肿瘤免疫反应以及癌症的生长、侵袭、转移、免疫逃逸和对治疗的抗性。钙（Ca2+）和镁（Mg2+）是广泛细胞过程所必需的两种离子，包括增殖、分化、迁移和蛋白质分泌。这两种离子的细胞内稳态和时空分布受到离子通道的严格调控，特别是瞬时受体电位褪黑素（TRPM）亚家族的成员，如TRPM2和TRPM7。TRPM2是一种由二磷酸腺苷核糖（ADPR）和活性氧（ROS）激活的Ca2+通透通道，而TRPM7既能通透Ca2+离子也能通透Mg2+离子，并表现出组成性活性。这两种通道都参与了氧化还原敏感信号传导，并在各种生理和病理环境（如癌症）中作为温度传感器发挥作用。在此，我们概述了TRPM2和TRPM7在调节TME内细胞动态方面的潜在作用，重点关注它们对免疫调节的贡献。
