The impact of colectomy on the quality of life in patients with chronic slow-transit constipation according to the pac-qol scale, depending on the histological subtype of the colonic wall.

OBJECTIVE

Aim: To assess the quality of life using the PAC-QOL scale in patients with chronic slow-transit constipation depending on the histological subtypes of the colonic wall after colectomy.

PATIENTS AND METHODS

Materials and Methods: The dynamics of quality-of-life scores were studied in 107 patients with slow-transit constipation resistant to conservative treatment after colectomy using PAC-QOL questionnaire.

RESULTS

Results: Significant improvement in quality of life was observed for all PAC-QOL subscales one year after surgery: physical discomfort improved by 58.7% to 67.7%, psychological discomfort - by 50.5%-67.2%, worries and concerns - by 53.3%- 67.6%, satisfaction with treatment - by 80.7%-82.6%, the PACQOL score - by 54-67.9%. The best outcomes for the PAC-QOL scale were demonstrated in patients with cajal subtype - 67,9% compared to the neuropathic (54,0%), myopathic inflammatory (56,1%), histologically intact (61,2%). Cajal histological subtype showed a greater improvement in the physical discomfort score - 67,7%, compared to the histologically intact subtype (58,7%), and the neuropathic subtype (58,9%); for Psychosocial discomfort - 67,2% compared to the dystrophic myopathic (55,5%), the neuropathic (50,7%), and the myopathic inflammatory subtype (50,5%); for the worries and concerns - 67,6% compared to the neuropathic subtype (53,3%).

CONCLUSION

Conclusions: In patients with STC resistant to conservative treatment, colectomy leads to significant improvement in quality of life according to the Pac-Qol questionnaire, one year after surgery with the best improvement for the Cajal subtype.