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InterPAD是一个关于植物化学物质与抗癌药物之间药物相互作用的数据库。

InterPAD is a database of drug-drug interaction between phytochemicals and anticancer drugs.

作者信息

Zhang Aili, Sun Xueni, Wu Qibiao, Jiang Haiyang, Xu Lihui, Gao Quan, Yang Zijing, Zhu Sisi, Sui Xinbing

机构信息

State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People's Republic of China.

School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.

出版信息

Sci Rep. 2025 Jul 9;15(1):24616. doi: 10.1038/s41598-025-10240-6.

DOI:10.1038/s41598-025-10240-6
PMID:40634546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12241595/
Abstract

The plant kingdom is a crucial source of potential medicines, with medicinal plants playing a significant role, they have been used to treat various diseases, including cancer. Phytochemicals have emerged as promising candidates for enhancing conventional cancer treatment strategies, particularly in addressing the persistent challenges associated with such therapies. For a long time, combined therapy has been widely adopted to overcome the limitations of monotherapies. To optimize therapeutic outcomes, it is crucial to understand the mechanisms underlying the interactions between phytochemicals and conventional drugs. Based on the above, we have developed a database named InterPAD, which serves as a valuable resource to retrieve detailed information on the interactions between phytochemicals and anticancer drugs. It offers insights into their mechanisms of action and therapeutic effects, thereby facilitating a deeper understanding of how these phytochemicals can be effectively integrated into modern cancer treatment protocols. A total of 1,055 interactions involving 331 phytochemicals and 244 anticancer drugs were meticulously reviewed and manually curated from the original publications into the InterPAD database. Additionally, InterPAD curates from 680 medicinal plants, providing detailed phytochemicals-related plant information. The database also includes 619 regulatory molecules and 74 cancer types, sourced from other databases, to elucidate cancer-specific molecular mechanism and therapeutic effects. To our knowledge, InterPAD is the first comprehensive database to investigate the synergistic or antagonistic interactions of phytochemicals with drugs across various cancer types. It uniquely highlights the biological effects of phytochemicals-based anticancer interactions through the framework of "multiple-regulatory molecules and multiple-signaling pathways", providing insights into their molecular mechanisms. This resource serves as a valuable tool for advancing research and improving cancer treatment strategies. InterPAD is accessible at: https://bddg.hznu.edu.cn/interpad/ .

摘要

植物王国是潜在药物的重要来源，药用植物发挥着重要作用，它们已被用于治疗包括癌症在内的各种疾病。植物化学物质已成为增强传统癌症治疗策略的有前景的候选物，特别是在应对与此类疗法相关的持续挑战方面。长期以来，联合疗法已被广泛采用以克服单一疗法的局限性。为了优化治疗效果，了解植物化学物质与传统药物之间相互作用的潜在机制至关重要。基于上述情况，我们开发了一个名为InterPAD的数据库，它是一个有价值的资源，用于检索有关植物化学物质与抗癌药物之间相互作用的详细信息。它提供了对其作用机制和治疗效果的见解，从而有助于更深入地了解这些植物化学物质如何有效地整合到现代癌症治疗方案中。我们从原始出版物中精心审查并手动整理了总共1055种涉及331种植物化学物质和244种抗癌药物的相互作用，并将其纳入InterPAD数据库。此外，InterPAD整理了680种药用植物的信息，提供了与植物化学物质相关的详细植物信息。该数据库还包括从其他数据库获取的619种调节分子和74种癌症类型，以阐明癌症特异性分子机制和治疗效果。据我们所知，InterPAD是第一个全面研究植物化学物质与各种癌症类型药物之间协同或拮抗相互作用的数据库。它通过“多种调节分子和多种信号通路”框架独特地突出了基于植物化学物质的抗癌相互作用的生物学效应，提供了对其分子机制的见解。这个资源是推进研究和改进癌症治疗策略的有价值工具。可通过以下网址访问InterPAD：https://bddg.hznu.edu.cn/interpad/ 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/03ce8c187e7c/41598_2025_10240_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/2c708e0623b0/41598_2025_10240_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/1a519129a2a8/41598_2025_10240_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/1076ae6d22cd/41598_2025_10240_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/a00617b7ba5f/41598_2025_10240_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/03ce8c187e7c/41598_2025_10240_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/2c708e0623b0/41598_2025_10240_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/1a519129a2a8/41598_2025_10240_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/02710ba32591/41598_2025_10240_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/07b9bda33682/41598_2025_10240_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/1076ae6d22cd/41598_2025_10240_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/a00617b7ba5f/41598_2025_10240_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005b/12241595/03ce8c187e7c/41598_2025_10240_Fig7_HTML.jpg

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