用全麦蜂粉（意大利蜜蜂）进行膳食补充对改善饮食诱导肥胖小鼠的代谢参数和调节脂肪生成基因的影响。
Dietary supplementation with wholemeal bee powder (Apis mellifera) effect on improving metabolic parameters and modulating lipogenesis genes in diet-induced obese mice.
作者信息
Pereira Joyce Hellyen Santos, Moraes Daniel Silva, Nascimento Aline Lopes, Barbosa Bruna Kaicy, Guimarães Victor Hugo Dantas, Cota Junio, Farias Lucyana Conceição, de Paula Alfredo Mauricio Batista, Guimarães André Luiz Sena, Santos Sérgio Henrique Sousa
机构信息
Health Science Laboratory, Postgraduate Program in Health Science, State University of Montes Claros (UNIMONTES), Montes Claros, MG, Brazil.
Institute of Agricultural Sciences (ICA), Postgraduate Program in Food and Health, Federal University of Minas Gerais (UFMG), Montes Claros, MG, Brazil.
出版信息
Mol Biol Rep. 2025 Jul 9;52(1):692. doi: 10.1007/s11033-025-10784-w.
BACKGROUND
Obesity resulting from an energy imbalance is a key factor in the development of several comorbidities. Traditional communities have historically used insects for their nutritional and therapeutic benefits, particularly in treating chronic diseases such as diabetes and obesity. The present study explores the bee (Apis mellifera) powder supplementation effects on metabolic parameters in mice with diet-induced obesity.
METHODS AND RESULTS
Male Swiss mice were subjected to a high-fat diet for three months, followed by a month of treatment with two different bee powder concentration additions. The animals were divided into four groups: standard diet, high-fat diet, high-fat with 15% bee powder, and high-fat with 30% bee powder. Bee powder supplementation reduced body weight and adipocyte size, promoting an increase in brown adipose tissue, decreasing glucose and cholesterol levels, and modulated the expression of FAS, ACC and GPX4.
CONCLUSION
These findings suggest bee powder's potential use for therapeutic applications in treating obesity and related conditions.
背景
能量失衡导致的肥胖是多种合并症发展的关键因素。传统社区长期以来利用昆虫获取营养和治疗益处，尤其是用于治疗糖尿病和肥胖等慢性疾病。本研究探讨了补充蜜蜂（意大利蜜蜂）粉对饮食诱导肥胖小鼠代谢参数的影响。
方法与结果
雄性瑞士小鼠接受三个月的高脂饮食，随后用两种不同浓度的蜜蜂粉添加物进行为期一个月的治疗。动物被分为四组：标准饮食组、高脂饮食组、添加15%蜜蜂粉的高脂饮食组和添加30%蜜蜂粉的高脂饮食组。补充蜜蜂粉可降低体重和脂肪细胞大小，促进棕色脂肪组织增加，降低血糖和胆固醇水平，并调节脂肪酸合酶（FAS）、乙酰辅酶A羧化酶（ACC）和谷胱甘肽过氧化物酶4（GPX4）的表达。
结论
这些发现表明蜜蜂粉在治疗肥胖及相关病症方面具有潜在的治疗应用价值。
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