Farahzadi S, Buckova M, Witzleben M Von, Schröder T A, Lauer G, Korn P
Department of Oral and Maxillofacial Surgery, Faculty of Medicine Carl Gustav Carus, University Hospital, Technische Universität Dresden, Dresden, Germany.
Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus, Faculty of Medicine Carl Gustav Caru, Technische Universität Dresden, Dresden, Germany.
Head Face Med. 2025 Jul 9;21(1):48. doi: 10.1186/s13005-025-00526-5.
Patients undergoing oral mucosa harvesting for urethroplasty may experience several challenges during recovery like scarring or changes in oral sensitivity, which can lead to long-term discomfort. In this retrospective study long-term donor site complications after harvesting of oral mucosa for urethroplasty were evaluated and a new measurement method for oral volume differences between the non-operated and operated sides was applied.
Thirty adult male patients who underwent urethroplasty with buccal mucosa grafting were included. At a median of 43 months after surgery, a standardized questionnaire was used, and clinical examinations were conducted to measure the postoperative elasticity of the buccal mucosa. This measurement compared the non-operated side with the operated side. Additionally, we examined descriptive statistics and the influence of smoking status, diabetes mellitus, immunosuppression, alcohol consumption, and graft size.
In total, 36% of the patients reported persistent subjective postoperative impairments, such as tightness in the oral cavity or numbness. In all patients, a difference in buccal volume was observed between the operated side and the non-operated side. This volume difference ranged from 3 to 15 ml (mean 8.10 ml, SD ± 3.4; p < 0.001). As the size of the harvested transplant increased, the postoperative buccal volume difference also increased significantly (p < 0.001). In one patient, follow-up surgery was required due to the severity of scarring. The presence of diabetes mellitus, immunosuppressive medication, smoking status, and alcohol consumption had no statistically significant effect on postoperative buccal elasticity or mouth opening.
The use of buccal mucosa grafts for urethroplasty is an established procedure in urology, but the oral harvesting procedure can lead to scarring within the buccal area, which is associated with a statistically significant decrease in buccal volume compared with the non-operated site. The volume analysis was performed by applying a new measurement method, which enables, for the first time, the quantification of oral donor site morbidity.
接受口腔黏膜采集用于尿道成形术的患者在恢复过程中可能会遇到一些挑战，如瘢痕形成或口腔敏感性变化，这可能导致长期不适。在这项回顾性研究中，评估了尿道成形术采集口腔黏膜后的长期供区并发症，并应用了一种新的测量方法来测量非手术侧和手术侧之间的口腔容积差异。
纳入30例接受颊黏膜移植尿道成形术的成年男性患者。在术后中位时间43个月时，使用标准化问卷，并进行临床检查以测量颊黏膜的术后弹性。该测量将非手术侧与手术侧进行比较。此外，我们检查了描述性统计数据以及吸烟状况、糖尿病、免疫抑制、饮酒和移植物大小的影响。
总体而言，36%的患者报告了持续的术后主观损伤，如口腔紧绷或麻木。在所有患者中，手术侧和非手术侧之间观察到颊部容积差异。该容积差异范围为3至15毫升（平均8.10毫升，标准差±3.4；p<0.001）。随着采集移植物大小的增加，术后颊部容积差异也显著增加（p<0.001）。1例患者因瘢痕严重需要进行后续手术。糖尿病、免疫抑制药物、吸烟状况和饮酒对术后颊部弹性或张口无统计学显著影响。
在泌尿外科，使用颊黏膜移植物进行尿道成形术是一种既定的手术方法，但口腔采集过程可导致颊部区域瘢痕形成，与非手术部位相比，颊部容积在统计学上显著减少。通过应用一种新的测量方法进行了容积分析，这首次实现了对口腔供区发病率的量化。
