Jiang Xiang, Luo Jia, Zhuo Dexiang, Chen Chunjing, Li Yaru, Chen Shiying, Sun Yingming, Lin Huanming
Department of Gynecology, Fujian Medical University Affiliated Sanming First Hospital, 29 Liedong Street, Sanming, 365000, Fujian, P.R. China.
Department of Gastroenterology, Fujian Medical University Affiliated Sanming First Hospital, Sanming, 365000, Fujian, China.
Infect Agent Cancer. 2025 Jul 9;20(1):45. doi: 10.1186/s13027-025-00678-8.
To study the prevalence of HPV in Sanming, China before conducting large-scale HPV vaccination is important to guide public health preventive measures and maximize the effectiveness of vaccination.
Provide an overall understanding of the prevalence of HPV in Sanming to help guide HPV screening and vaccine selection in the future.
A retrospective analysis of 11,886 female patients who underwent cervical screening was performed. We analyzed the overall HPV prevalence in the region, the prevalence based on each age group and different genotypes and the distribution of HPV with different pathological diagnoses.
The overall HPV prevalence was 17.85%, with peak positivity in the ≤ 20-year group (42.24%) and secondary elevation in 61-70-year-olds (31.90%). HPV52 (23.37%), HPV58 (14.00%), and HPV16 (11.40%) constituted the dominant genotypes. Among 2,122 HPV-positive patients, pathological diagnoses included: chronic cervicitis (83.22%, 1,766/2,122; predominantly HPV52 [22.88%]), low-grade squamous intraepithelial lesions (LSIL, 11.50%, 244/2,122; HPV52 [29.92%]), high-grade SIL (HSIL, 3.49%, 74/2,122; HPV16 [40.54%]), and cervical cancer (1.79%, 38/2,122; HPV16 [52.63%]). Notably, HPV16 prevalence increased significantly with lesion severity.
This study found that the overall HPV infection rate in Sanming, China, was slightly higher than in other regions of the country, and the main prevalent genotypes were HPV52 and HPV58. In order to maximize patient benefit, vaccine selection should ideally cover other common genotypes in the region, in addition to HPV16 and HPV18.
在开展大规模人乳头瘤病毒（HPV）疫苗接种之前，研究中国三明地区HPV的流行情况对于指导公共卫生预防措施以及最大化疫苗接种效果具有重要意义。
全面了解三明地区HPV的流行情况，以助力未来指导HPV筛查和疫苗选择。
对11886例接受宫颈筛查的女性患者进行回顾性分析。我们分析了该地区HPV的总体流行率、各年龄组及不同基因型的流行率以及不同病理诊断下HPV的分布情况。
HPV总体流行率为17.85%，在≤20岁组中阳性率最高（42.24%），在61 - 70岁组中呈次高峰（31.90%）。HPV52（23.37%）、HPV58（14.00%）和HPV16（11.40%）为主要基因型。在2122例HPV阳性患者中，病理诊断包括：慢性宫颈炎（83.22%，1766/2122；主要为HPV52 [22.88%]）、低级别鳞状上皮内病变（LSIL，11.50%，244/2122；HPV52 [29.92%]）、高级别鳞状上皮内病变（HSIL，3.49%，74/2122；HPV16 [40.54%]）和宫颈癌（1.79%，38/2122；HPV16 [52.63%]）。值得注意的是，HPV16的流行率随病变严重程度显著增加。
本研究发现，中国三明地区HPV总体感染率略高于国内其他地区，主要流行基因型为HPV52和HPV58。为使患者受益最大化，除HPV16和HPV18外，疫苗选择理想情况下应涵盖该地区其他常见基因型。
