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经峡部入路行胸段硬膜外神经鞘瘤囊内切除术:41例病例系列的临床可行性研究

Intracapsular Resection of Thoracic Extradural Schwannomas via the Isthmic Approach: Investigation of Clinical Feasibility With 41 Case Series.

作者信息

Gao Wei, Hu Xinben, Liu Tianjian, Chen Aiqin, Chen Jingyin, Gu Chi, Ying Guangyu, Wang Qiangwei, Zhu Yongjian

机构信息

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China.

出版信息

CNS Neurosci Ther. 2025 Jul;31(7):e70506. doi: 10.1111/cns.70506.

Abstract

OBJECTIVE

Thoracic spinal canal schwannomas can pose surgical challenges when extending into intra- and extra-foraminal regions and the thoracic cavity. This article aims to elucidate the technical nuances and clinical feasibility of the isthmic approach for treating thoracic extradural schwannomas via intracapsular resection.

METHODS

The surgical technique was meticulously outlined, and a retrospective analysis of 41 patients who underwent thoracic schwannoma resection via the isthmic approach between January 2014 and August 2022 was conducted. Parameters including gross total resection (GTR) rate, operative duration, estimated blood loss (EBL), incision length, and postoperative hospital stay were evaluated. Preoperative and postoperative neurosurgical functions were assessed using the modified McCormick functional schema and Visual Analogue Scale (VAS).

RESULT

All patients achieved GTR, with an operative time of 125.37 ± 45.17 min, an average incision length of 6.56 ± 1.04 cm, and an estimated blood loss of 69.88 ± 86.54 mL. The average hospital stay was 6.76 ± 3.73 days. The VAS score significantly decreased postoperatively (preoperative vs. postoperative: 2.10 ± 0.85 vs. 1.32 ± 0.47, p < 0.001).

CONCLUSION

The isthmic approach via intracapsular resection is a promising method for treating extradural schwannomas extending into intra- and extra-foraminal regions. This approach enhances total tumor resection rates, preserves spinal stability, and significantly reduces operative duration, incision length, and blood loss.

摘要

目的

当胸段椎管神经鞘瘤延伸至椎间孔内和椎间孔外区域以及胸腔时,手术治疗会面临挑战。本文旨在阐明通过囊内切除治疗胸段硬膜外神经鞘瘤的峡部入路的技术细节和临床可行性。

方法

详细描述了手术技术,并对2014年1月至2022年8月间采用峡部入路行胸段神经鞘瘤切除术的41例患者进行了回顾性分析。评估了包括全切除率、手术时间、估计失血量、切口长度和术后住院时间等参数。使用改良的麦考密克功能分级法和视觉模拟量表(VAS)评估术前和术后的神经外科功能。

结果

所有患者均实现全切除,手术时间为125.37±45.17分钟,平均切口长度为6.56±1.04厘米,估计失血量为69.88±86.54毫升。平均住院时间为6.76±3.73天。术后VAS评分显著降低(术前与术后:2.10±0.85 vs. 1.32±0.47,p<0.001)。

结论

通过囊内切除的峡部入路是治疗延伸至椎间孔内和椎间孔外区域的硬膜外神经鞘瘤的一种有前景的方法。该方法提高了肿瘤全切除率,保留了脊柱稳定性,并显著缩短了手术时间、切口长度和失血量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c57c/12241823/e04d7ae3b20f/CNS-31-e70506-g003.jpg

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