Barnes P J, Cuss F M, Palmer J B
Br J Pharmacol. 1985 Nov;86(3):685-91. doi: 10.1111/j.1476-5381.1985.tb08946.x.
In bovine tracheal smooth muscle the presence of airway epithelium significantly reduced the sensitivity and maximum contractile response to histamine, 5-hydroxytryptamine (5-HT) or acetylcholine. Muscle contraction induced by K+ and electrical field stimulation was of similar magnitude both in the presence or absence of adherent epithelium. The effect of epithelium on smooth muscle contractility was unaffected by pretreatment with indomethacin (10(-6) M) or mepacrine (5 X 10(-5) M). The relaxant response to isoprenaline was enhanced in the presence of epithelium, although this was significant only in the case of precontraction with 5-HT. It is concluded that the bronchial epithelium may produce a relaxant factor which is not a cyclooxygenase or lipoxygenase product. The production of this factor may be reduced or lost following epithelial damage and this may be important in the pathogenesis of bronchial hyperresponsiveness in asthma.
在牛气管平滑肌中，气道上皮的存在显著降低了对组胺、5-羟色胺（5-HT）或乙酰胆碱的敏感性和最大收缩反应。在有或没有附着上皮的情况下，由钾离子（K+）和电场刺激诱导的肌肉收缩幅度相似。上皮对平滑肌收缩性的影响不受吲哚美辛（10⁻⁶ M）或米帕林（5×10⁻⁵ M）预处理的影响。在有上皮存在的情况下，对异丙肾上腺素的舒张反应增强，尽管这仅在5-HT预收缩的情况下才显著。结论是支气管上皮可能产生一种舒张因子，它不是环氧化酶或脂氧化酶的产物。上皮损伤后这种因子的产生可能会减少或丧失，这在哮喘支气管高反应性的发病机制中可能很重要。
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