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通过减少氧化应激和炎症，可溶解微针辅助双醋瑞因纳米颗粒经皮给药在肌腱-骨附着点修复中取得了令人满意的治疗效果。

Dissolvable microneedle-assisted transdermal administration of diacerein nanoparticles achieved satisfactory therapeutic effects in tendon-bone insertion repair by reducing oxidative stress and inflammation.

作者信息

Sun Jie, Chen Qing Zhong, Hong Ai Zi, Ju Fei, Wang Hao Liang, Zhang Bo, Liu Wang, Sun Yu Cheng, Tan Jun, Yang Qian Qian, Zhou You Lang

机构信息

Hand Surgery Research Center, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.

出版信息

Mater Today Bio. 2025 Jun 18;33:101999. doi: 10.1016/j.mtbio.2025.101999. eCollection 2025 Aug.

DOI:10.1016/j.mtbio.2025.101999
PMID:40636026
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12240096/
Abstract

Tendon-bone insertion injuries are frequently encountered in sports medicine clinics, with the healing process posing a significant challenge within this field. When it comes to non-surgical interventions for such injuries, the use of local drug injections may carry the risk of damaging peripheral nerves and blood vessels. In this study, a simple dissolvable microneedle (DMN) patch loaded with diacerein (Dia) nanoparticles (DMN/PLGA@Dia) is established to achieve a constant delivery of Dia for enhancing tendon-bone healing. experiments demonstrate that Dia alleviates oxidative stress, reduces apoptosis, and prevents senescence in tendon cells, while also polarizing macrophages to the M2 phenotype. In a rat model of Achilles tendon-bone insertion injury, the application of DMN/PLGA@Dia enhances the regeneration of the tendon-bone insertion by reducing reactive oxygen species (ROS) levels and shifting macrophage polarization from M1 to M2. Additionally, DMN/PLGA@Dia improves functional recovery, as evidenced by biomechanical and gait analyses. These findings suggest that DMN/PLGA@Dia is capable of promoting tendon-bone insertion repair by alleviating oxidative stress and regulating the immune microenvironment strategies. Simple DMN/PLGA@Dia may be an effective and safe nanomedicine delivery system for tendon-bone insertion repair.

摘要

肌腱-骨插入伤在运动医学诊所中经常遇到，其愈合过程给该领域带来了重大挑战。对于此类损伤的非手术干预，局部药物注射可能存在损伤周围神经和血管的风险。在本研究中，制备了一种负载双醋瑞因（Dia）纳米颗粒的简单可溶解微针（DMN）贴片（DMN/PLGA@Dia），以实现Dia的持续递送，促进肌腱-骨愈合。实验表明，Dia可减轻肌腱细胞中的氧化应激、减少细胞凋亡并防止细胞衰老，同时还能使巨噬细胞极化为M2表型。在跟腱-骨插入伤的大鼠模型中，应用DMN/PLGA@Dia可通过降低活性氧（ROS）水平以及将巨噬细胞极化从M1转变为M2来促进肌腱-骨插入处的再生。此外，生物力学和步态分析表明，DMN/PLGA@Dia可改善功能恢复。这些发现表明，DMN/PLGA@Dia能够通过减轻氧化应激和调节免疫微环境策略来促进肌腱-骨插入处的修复。简单的DMN/PLGA@Dia可能是一种用于肌腱-骨插入修复的有效且安全的纳米药物递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/e4a1a19bb216/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/4792b4eee01f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/45f0de3dda9e/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/8f57cdb61a04/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/9e51d7e4366a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/a197e76fbdb0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/28f4e2cd1d5c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/1edfbf0bd4c1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/7558db29f3a5/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/ebb1b7d66bc9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/e4a1a19bb216/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/4792b4eee01f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/45f0de3dda9e/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/8f57cdb61a04/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/9e51d7e4366a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/a197e76fbdb0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/28f4e2cd1d5c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/1edfbf0bd4c1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/7558db29f3a5/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/ebb1b7d66bc9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1861/12240096/e4a1a19bb216/gr8.jpg

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