O'Brien John T
Department of Psychiatry University of Cambridge Cambridge UK.
Alzheimers Dement (Amst). 2025 Jul 9;17(3):e70145. doi: 10.1002/dad2.70145. eCollection 2025 Jul-Sep.
Many people with dementia with Lewy bodies (DLB) have evidence of Alzheimer's disease (AD) co-pathology, which can be assessed in vivo using biomarkers. In this issue, Armstrong and colleagues argue that it is now timely to disclose such AD biomarker results to people with DLB. They provide logical and powerful arguments, including the right for people to know and the value of this information in informing outcome and management. However, there are also important caveats to consider and a careful balance needs to be maintained between, on the one hand, the right to know and convey clinically useful information and, on the other, acknowledging the real uncertainty that exists regarding the true diagnostic and management implications of AD biomarkers in an individual with a DLB rather than an AD clinico-pathological syndrome.
许多路易体痴呆(DLB)患者存在阿尔茨海默病(AD)共病病理的证据,这可以通过生物标志物在体内进行评估。在本期杂志中,阿姆斯特朗及其同事认为,现在向DLB患者披露此类AD生物标志物结果恰逢其时。他们提出了合乎逻辑且有力的论据,包括人们了解的权利以及这些信息在指导预后和管理方面的价值。然而,也有一些重要的注意事项需要考虑,并且需要在一方面了解和传达临床有用信息的权利,与另一方面承认在患有DLB而非AD临床病理综合征的个体中,AD生物标志物的真正诊断和管理意义存在的实际不确定性之间保持谨慎的平衡。