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Genetic research on MASLD: New insights into cardiovascular disease and cancer risk.

作者信息

Yang Ming, Liu Juan

机构信息

Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, Key Laboratory of Digital Intelligence Hepatology (Ministry of Education/Beijing), School of Clinical Medicine, Tsinghua University, Beijing 102218, China.

出版信息

ILIVER. 2024 Aug 10;3(3):100108. doi: 10.1016/j.iliver.2024.100108. eCollection 2024 Sep.

DOI:10.1016/j.iliver.2024.100108
PMID:40636087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12212651/
Abstract
摘要

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ILIVER. 2024 Aug 10;3(3):100108. doi: 10.1016/j.iliver.2024.100108. eCollection 2024 Sep.
2
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本文引用的文献

1
Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer.与肝脂肪相关的不同遗传变异及其与心血管疾病和癌症的相反关系。
J Hepatol. 2024 Dec;81(6):921-929. doi: 10.1016/j.jhep.2024.06.030. Epub 2024 Jul 1.
2
Implications of the evolving knowledge of the genetic architecture of MASLD.代谢相关脂肪性肝病（MASLD）遗传结构不断演变的知识所带来的影响。
Nat Rev Gastroenterol Hepatol. 2024 Jan;21(1):5-6. doi: 10.1038/s41575-023-00866-0.
3
Unraveling the pathogenesis of non-alcoholic fatty liver diseases through genome-wide association studies.通过全基因组关联研究揭示非酒精性脂肪性肝病的发病机制。
J Gastroenterol Hepatol. 2023 Nov;38(11):1877-1885. doi: 10.1111/jgh.16330. Epub 2023 Aug 17.
4
Dissecting causal relationships between nonalcoholic fatty liver disease proxied by chronically elevated alanine transaminase levels and 34 extrahepatic diseases.剖析以慢性升高的丙氨酸转氨酶水平为代表的非酒精性脂肪性肝病与34种肝外疾病之间的因果关系。
Metabolism. 2022 Oct;135:155270. doi: 10.1016/j.metabol.2022.155270. Epub 2022 Jul 29.
5
Associations of muscle mass and grip strength with severe NAFLD: A prospective study of 333,295 UK Biobank participants.肌肉质量和握力与严重非酒精性脂肪性肝病的相关性：英国生物库 333295 名参与者的前瞻性研究。
J Hepatol. 2022 May;76(5):1021-1029. doi: 10.1016/j.jhep.2022.01.010. Epub 2022 Jan 24.
6
The Health Impact of MAFLD, a Novel Disease Cluster of NAFLD, Is Amplified by the Integrated Effect of Fatty Liver Disease-Related Genetic Variants.MAFLD 对健康的影响，一种新型的非酒精性脂肪性肝病疾病群，通过与脂肪性肝病相关的遗传变异的综合效应而放大。
Clin Gastroenterol Hepatol. 2022 Apr;20(4):e855-e875. doi: 10.1016/j.cgh.2020.12.033. Epub 2020 Dec 30.
7
Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.利用多基因风险评分对非酒精性脂肪性肝病进行肝细胞癌风险的无创分层。
J Hepatol. 2021 Apr;74(4):775-782. doi: 10.1016/j.jhep.2020.11.024. Epub 2020 Nov 25.
8
Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping.非酒精性脂肪性肝病、2 型糖尿病和肥胖之间的因果关系对疾病亚表型有影响。
J Hepatol. 2020 Aug;73(2):263-276. doi: 10.1016/j.jhep.2020.03.006. Epub 2020 Mar 10.