.抗黑色素瘤作用的分子实体
Molecular entities for the anti-melanoma effect of .
作者信息
Sakharkar Neha, Kaul-Ghanekar Ruchika, Song Yingying, Yang Jian
机构信息
Bharati Vidyapeeth University, Pune - 411043, Maharashtra, India.
Symbiosis School of Biological Sciences (SSBS), Symbiosis Centre for Research and Innovation (SCRI), Symbiosis International (Deemed University), Pune - 412115, Maharashtra, India.
出版信息
Bioinformation. 2025 Apr 30;21(4):679-694. doi: 10.6026/973206300210679. eCollection 2025.
Prognosis for advanced and metastatic melanoma remains poor despite low incidence rate and early diagnosis. A significant number of melanoma patients use complementary and alternative medicines during their normal treatments in anticipating improving therapeutic efficacy. shows effective inhibitory activity against melanoma cells compared to , , and . Therefore, it is of interest to explore the anti-melanoma entities of . Our data show that three unique melanoma-related gene targets (CYP3A4, GBA2 and PTK6) for two unique active ingredients (diosgenin and solanocapsine) present in have potential role.
尽管晚期和转移性黑色素瘤的发病率较低且能早期诊断，但其预后仍然很差。相当数量的黑色素瘤患者在常规治疗期间使用补充和替代药物，期望提高治疗效果。与[具体药物1]、[具体药物2]和[具体药物3]相比，[药物名称]对黑色素瘤细胞显示出有效的抑制活性。因此，探索[药物名称]的抗黑色素瘤成分具有重要意义。我们的数据表明，[药物名称]中存在的两种独特活性成分（薯蓣皂苷元和茄解碱）的三个与黑色素瘤相关的独特基因靶点（CYP3A4、GBA2和PTK6）具有潜在作用。
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