基孔肯雅病毒在高危孕妇中的血清学调查及胎盘组织研究结果
Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings.
作者信息
Fajardo Thamirys Cosmo Grillo, Quadros Junior Antonio Carlos de, Pinto Clóvis Antonio Lopes, Santos Geovane Ribeiro Dos, Silva Andrea Cristina Botelho da, Catalan Daniel Thome, Bertozzi Ana Paula Antunes Pascalicchio, Gazeta Rosa Estela, Moron Antonio Fernandes, Passos Saulo Duarte, Mello Alexandra Siqueira, Soriano-Arandes Antoni, Alarcon Ana, Garcia-Alix Alfredo, Silva Alify Bertoldo da, Ventura Dora Fix, Oliveira Danielle Bruna Leal de, Tambalo Danilla Soares, Lima Diego da Silva, Fujiwara Dirce Takako, Durigon Edison Luiz, Bagne Eduardo Roberto, Velasco Fernanda Guerra, Baran Luiz Claudio Portnoi, Arita Fernando Novo, Hernandez Francisco Del Moral, Almeida Juliana Paula Gomes de, Camandulli Karen Richter, Castro Lucas Pires de, Machado Márcia Borges, Zatz Mayana, Rodrigues Maria Manoela Duarte, Rizzo Maria de Fátima Valente, Farrão Maria Amélia, Leite Mirella Nayane Barbosa, Florence Filho Nemésio, Loiola Patrícia Carvalho, Prestes Raquel, Dezena Rita de Cássia Aguirre, Bonon Sandra Helena Alves, Vranjac Sergio, Rosemberg Sérgio, Sarmento Stephanno Gomes Pereira, Witkinchi Steven Sol, Souza Tathiana Ghisi de, Pandini Viviane Cristina Martori, Paiva Viviam Paschoarelli
机构信息
Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, São Paulo, Brazil.
Faculdade de Medicina de Jundiaí, Departamento de Morfologia e Patologia Básica, Jundiaí, São Paulo, Brazil.
出版信息
Rev Inst Med Trop Sao Paulo. 2025 Jul 7;67:e43. doi: 10.1590/S1678-9946202567043. eCollection 2025.
Evidence suggests a risk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns.
有证据表明，在妊娠早期和晚期存在基孔肯雅病毒（CHIKV）母婴传播的风险，这可能导致胎儿流产或出现神经方面的后果。本研究旨在对高危妊娠女性进行CHIKV血清学调查，并分析新生儿变量和胎盘组织改变。2016年3月至2021年4月，对CHIKV进行了血清学、组织学和分子检测。分析血样中的抗CHIKV IgG和IgM抗体，并检查胎盘组织中的CHIKV RNA和组织学变化。在孕妇中，1.33%（7/526）在分娩时有反应性IgG，0.38%（2/526）有IgM/IgG型抗体。尽管CHIKV疾病的胎盘组织学显示有改变，但在所分析的组织中未发现病毒遗传物质。因此，需要进一步研究，包括使用补充诊断技术，以更好地了解这种相对较新的疾病对高危孕妇和新生儿的影响。
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