Lin C C, De Braekeleer M, Jamro H
Can J Genet Cytol. 1985 Oct;27(5):565-70. doi: 10.1139/g85-083.
In a series of 493 apparently consecutive products of spontaneous abortions obtained for cytogenetic studies, tissue culture was attempted in 428 cases; chromosome analysis using the Q-banding technique was completed in 215 cases (50.2%). Abnormal karyotypes were identified in 80 cases (37.2%). Maternal tissue contamination was apparent and the actual frequency of karyotypic abnormal abortuses could be as high as 50%. Comparison of the frequency of a specific type of chromosome abnormalities with nine other series of studies showed the lowest frequency of autosomal trisomies and the highest frequency of triploidies and structural aberrations in the Calgary series. In addition, a significantly lower gestational age was observed for triploidies 69, XXX as compared to the 69, XXY.
在为细胞遗传学研究获取的一系列493例明显连续的自然流产产物中，对428例进行了组织培养尝试；采用Q显带技术完成了215例（50.2%）的染色体分析。在80例（37.2%）中鉴定出异常核型。母体组织污染明显，核型异常流产的实际发生率可能高达50%。将一种特定类型的染色体异常频率与其他九项系列研究进行比较，结果显示卡尔加里系列中常染色体三体的频率最低，三倍体和结构畸变的频率最高。此外，与69, XXY三倍体相比，观察到69, XXX三倍体的妊娠年龄明显更低。
