• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs.

作者信息

Rosowsky A, Ensminger W D, Lazarus H, Yu C S

出版信息

J Med Chem. 1977 Jul;20(7):925-30. doi: 10.1021/jm00217a012.

DOI:10.1021/jm00217a012
PMID:406398
Abstract
摘要

相似文献

1
Methotrexate analogues. 8. Synthesis and biological evaluation of bisamide derivatives as potential prodrugs.
J Med Chem. 1977 Jul;20(7):925-30. doi: 10.1021/jm00217a012.
2
Methotrexate analogs. 4.7-Methyl derivatives of methotrexate and dichloromethotrexate. A new synthesis and some biological studies.
J Med Chem. 1974 Dec;17(12):1308-11. doi: 10.1021/jm00258a016.
3
Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues.
J Med Chem. 1979 Jul;22(7):869-74. doi: 10.1021/jm00193a022.
4
Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues.
J Med Chem. 1977 Oct;20(10):1323-7. doi: 10.1021/jm00220a019.
5
Methotrexate analogues. 14. Synthesis of new gamma-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents.甲氨蝶呤类似物。14. 新型γ-取代衍生物作为二氢叶酸还原酶抑制剂和潜在抗癌剂的合成。
J Med Chem. 1981 Dec;24(12):1450-5. doi: 10.1021/jm00144a016.
6
Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
J Med Chem. 1974 Nov;17(11):1212-6. doi: 10.1021/jm00257a015.
7
Activation by peptidases and cytotoxicity of 2-(L-alpha-aminoacyl) prodrugs of methotrexate.
Adv Exp Med Biol. 1993;338:457-60. doi: 10.1007/978-1-4615-2960-6_92.
8
Quantitative correlations of biological activities of dactinomycin analogs and methotrexate derivatives with van der Waals volume.
Arzneimittelforschung. 1985;35(7):1030-3.
9
Synthesis of a fluorescent derivative of amethopterin,
J Med Chem. 1975 May;18(5):526-8. doi: 10.1021/jm00239a020.
10
Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification.
J Med Chem. 1973 Oct;16(10):1190-3. doi: 10.1021/jm00268a029.

引用本文的文献

1
Efficacies of lipophilic inhibitors of dihydrofolate reductase against parasitic protozoa.二氢叶酸还原酶亲脂性抑制剂对寄生原生动物的疗效。
Antimicrob Agents Chemother. 2001 Jan;45(1):187-95. doi: 10.1128/AAC.45.1.187-195.2001.
2
Pharmacologic studies on the dibutyl and gamma-monobutyl esters of methotrexate in the rhesus monkey.甲氨蝶呤二丁酯和γ-单丁酯在恒河猴体内的药理学研究。
Cancer Chemother Pharmacol. 1982 Dec;10(1):55-61. doi: 10.1007/BF00257240.