Zhao Juan, Yu Jiaofeng, Fu Ye, Zhao Yan, Zhao Mingli
Kunming Medical University, Kunming 650500, China.
Three Departments in the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Zhongguo Fei Ai Za Zhi. 2025 Jun 20;28(6):482-486. doi: 10.3779/j.issn.1009-3419.2025.102.26.
Lung cancer represents one of the most prevalent malignant tumors globally, and its treatment has entered the era of targeted therapy. The epidermal growth factor receptor (EGFR) mutation is a common type of genetic mutation in non-small cell lung cancer (NSCLC), while c-ros oncogene 1 receptor tyrosine kinase (ROS-1) fusion mutation is a rare mutation site. Currently, there are few case reports on the coexistence of EGFR and ROS-1 gene mutations. This study reports a case of NSCLC with coexisting EGFR and ROS-1 gene mutations, aiming to provide relevant treatment strategies for clinical practice. .
肺癌是全球最常见的恶性肿瘤之一,其治疗已进入靶向治疗时代。表皮生长因子受体(EGFR)突变是非小细胞肺癌(NSCLC)中常见的基因突变类型,而c-ros原癌基因1受体酪氨酸激酶(ROS-1)融合突变是一个罕见的突变位点。目前,关于EGFR和ROS-1基因突变共存的病例报告较少。本研究报告了1例EGFR和ROS-1基因突变共存的NSCLC病例,旨在为临床实践提供相关治疗策略。