埃及儿童静脉血栓栓塞症管理的儿科指南：改编方法：资源有限国家的视角
Egyptian pediatric guidelines for the management of childhood venous thromboembolism: the adapted methodology: a limited resource country perspective.
作者信息
Mokhtar Galila, Abdelbaky Ashraf, Adly Amira, Ezzat Dina, Hafez Hanafy, Hassab Hoda, Youssry Ilham, Ragab Iman, Sherief Laila M, Zakaria Marwa, Hesham Mervat, Mansour Mervat, Shaheen Naglaa, Omar Tarek, Afifi Rasha Abdel-Raouf Abdelaziz, Makkeyah Sara, Adolf Sonia, Amer Yasser, Hussein Heba, Ibrahim Hanan, Salama Khaled, Darwish Ahmad, Brandao Leonardo R, Florez Ivan, Khalifa Gehan Lotfy Abdel Hakeem
机构信息
Pediatric Hematology and Oncology Unit, Pediatric Department, Ain Shams University, Cairo, Egypt.
Pediatrics and Pediatric Allergy and Immunology, Ain Shams University, Cairo, Egypt.
出版信息
Thromb J. 2025 Jul 10;23(1):74. doi: 10.1186/s12959-025-00758-0.
BACKGROUND
Thrombosis is a major pediatric health problem with a spectrum of etiologies, clinical presentations, and morbidities. Establishing the diagnosis and treatment of pediatric thrombosis with different site-related presentations may be challenging. This article adapts the high-quality Clinical Practice Guidelines (CPGs) for pediatric thrombosis management to suit the Egyptian healthcare context.
METHODS
The adapted ADAPTE methodology was used to identify the high-quality CPGs published between 2012 and 2023. An expert panel screened, reviewed, and assessed the CPGs and formulated the adapted consensus recommendations based on the best available evidence.
RESULTS
The final CPG document provides consensus recommendations and implementation tools for managing thrombosis with different etiologies in children and adolescents in Egypt. There is no evidence to support strong recommendations for various management approaches.
CONCLUSIONS
In general, a complete clinical and radiological assessment and some laboratory tests are indicated at the initial diagnosis to confirm a thrombotic disorder and to further choose the type of workup required. Future research should report the outcome of this adapted guideline and include cost-analysis evaluations.
背景
血栓形成是一个主要的儿科健康问题，其病因、临床表现和发病率各不相同。对于具有不同部位相关表现的儿科血栓形成进行诊断和治疗可能具有挑战性。本文对儿科血栓形成管理的高质量临床实践指南（CPG）进行了调整，以适应埃及的医疗环境。
方法
采用改编后的ADAPTE方法来识别2012年至2023年期间发表的高质量CPG。一个专家小组对CPG进行了筛选、审查和评估，并根据现有最佳证据制定了改编后的共识建议。
结果
最终的CPG文件为埃及儿童和青少年不同病因的血栓形成管理提供了共识建议和实施工具。没有证据支持对各种管理方法提出强有力的建议。
结论
一般来说，在初始诊断时需要进行全面的临床和放射学评估以及一些实验室检查，以确认血栓形成疾病并进一步选择所需的检查类型。未来的研究应报告该改编指南的结果，并包括成本分析评估。
Zotero 插件