阻断白细胞介素-6通路治疗免疫检查点抑制剂诱导的炎性关节炎（综述）
Blocking the IL‑6 pathway to treat immune checkpoint inhibitor‑induced inflammatory arthritis (Review).
作者信息
Zhao Liwen, Feng Chuting, Gao Yong-Jing, He Tianzhen
机构信息
Institute of Pain Medicine and Special Environmental Medicine, Co‑innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226019, P.R. China.
出版信息
Mol Med Rep. 2025 Sep;32(3). doi: 10.3892/mmr.2025.13615. Epub 2025 Jul 11.
The incorporation of immune checkpoint inhibitors (ICIs) into cancer treatment has revolutionized oncology, providing marked advantages in managing various types of cancer. Nevertheless, the increasing use of ICIs has led to the emergence of immune‑related side effects, including autoimmune diseases such as inflammatory arthritis. IL‑6 signaling is crucial in the development of inflammatory arthritis and is linked to both the benefits and adverse effects of ICIs. The present review summarizes the latest progress in the IL‑6 pathway in inflammatory arthritis and discusses the therapeutic potential of IL‑6 pathway inhibitors for ICI‑induced inflammatory arthritis.
免疫检查点抑制剂（ICI）纳入癌症治疗已彻底改变了肿瘤学，在管理各类癌症方面具有显著优势。然而，ICI使用的增加导致了免疫相关副作用的出现，包括炎症性关节炎等自身免疫性疾病。白细胞介素-6（IL-6）信号传导在炎症性关节炎的发展中至关重要，并且与ICI的益处和不良反应均相关。本综述总结了炎症性关节炎中IL-6信号通路的最新进展，并讨论了IL-6信号通路抑制剂对ICI诱导的炎症性关节炎的治疗潜力。
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