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肺阴亏虚型喉源性咳嗽的上呼吸道微生物群变化及养阴清肺口服液的调节作用

Altered upper respiratory tract microbiota in laryngeal cough attributed to lung yin deficiency and the modulatory effects of Yangyin Qingfei Oral Liquid.

作者信息

Yu Fei, Jin Jing, Jin Xinlai, Ding Xuchun, Lou Yafang

机构信息

Department of Respiratory and Critical Care Medicine, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Graduate School, Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Front Microbiol. 2025 Jun 26;16:1592294. doi: 10.3389/fmicb.2025.1592294. eCollection 2025.

DOI:10.3389/fmicb.2025.1592294
PMID:40641875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12241029/
Abstract

OBJECTIVE

This study investigates changes in upper respiratory tract microbiota in laryngeal cough patients with lung yin deficiency using high-throughput sequencing of the 16S rDNA gene. It also examines the modulatory effects of Yangyin Qingfei Oral Liquid (YYQFOL).

METHODS

We included 100 laryngeal cough patients and 65 healthy subjects, collecting throat swab samples for microbiota comparison. Patients were randomly assigned to a control group receiving methoxyphenamine capsules and an experimental group receiving YYQFOL and methoxyphenamine for 10 days. We assessed changes in microbiota, symptom scoring, and Leicester Cough Questionnaire (LCQ) results. Each group was divided into responders (R) and non-responders (NR).

RESULTS

Patients with laryngeal cough had significantly lower microbial abundance and diversity than healthy subjects ( < 0.05). After treatment, symptom scores and LCQ results improved significantly ( < 0.05), with responders in the experimental group (ER) showing significantly better improvement than those in the responders in the control group (CR) ( < 0.05). Post-treatment, the experimental group saw a significant reduction in , , and other genera, while increased ( < 0.05).

CONCLUSION

Laryngeal cough patients with lung yin deficiency are imbalanced in the upper respiratory tract microbiota. Treatment with methoxyphenamine and YYQFOL improves microbiota composition and alleviates symptoms.

摘要

目的

本研究采用16S rDNA基因高通量测序技术，调查肺阴亏虚型喉源性咳嗽患者上呼吸道微生物群的变化。同时考察养阴清肺口服液（YYQFOL）的调节作用。

方法

纳入100例喉源性咳嗽患者和65例健康受试者，采集咽拭子样本进行微生物群比较。患者随机分为接受甲氧那明胶囊的对照组和接受YYQFOL及甲氧那明治疗10天的试验组。我们评估了微生物群的变化、症状评分和莱斯特咳嗽问卷（LCQ）结果。每组又分为应答者（R）和无应答者（NR）。

结果

喉源性咳嗽患者的微生物丰度和多样性显著低于健康受试者（<0.05）。治疗后，症状评分和LCQ结果显著改善（<0.05），试验组应答者（ER）的改善明显优于对照组应答者（CR）（<0.05）。治疗后，试验组的、、等属显著减少，而属增加（<0.05）。

结论

肺阴亏虚型喉源性咳嗽患者上呼吸道微生物群失衡。甲氧那明和YYQFOL治疗可改善微生物群组成并减轻症状。

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