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与服用半夏泻心汤相关的药物性肝损伤。

Drug-induced liver injury associated with exposure to Hangeshashinto.

作者信息

Kubo Kimitoshi, Ashida Issei, Kimura Noriko

机构信息

Department of Gastroenterology National Hospital Organization Hakodate Medical Center Hakodate Hokkaido Japan.

Department of Pathology National Hospital Organization Hakodate Medical Center Hakodate Hokkaido Japan.

出版信息

J Gen Fam Med. 2025 Apr 24;26(4):370-371. doi: 10.1002/jgf2.70018. eCollection 2025 Jul.

DOI:10.1002/jgf2.70018
PMID:40642131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12237816/
Abstract

While Kampo medicines are deemed relatively safe and associated with few adverse effects, primary care physicians are well advised to be aware of the risk of drug-induced liver injury in patients prescribed Kampo medicines containing Scutellariae radix, such as Hangeshashinto, in clinical practice and to closely monitor their clinical course.

摘要

虽然汉方药物被认为相对安全且不良反应较少，但在临床实践中，强烈建议初级保健医生了解在给患者开具含有黄芩（如半夏泻心汤）的汉方药物时药物性肝损伤的风险，并密切监测其临床病程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d5/12237816/445387a21a26/JGF2-26-370-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d5/12237816/445387a21a26/JGF2-26-370-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39d5/12237816/445387a21a26/JGF2-26-370-g002.jpg

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本文引用的文献

1
Kampo medicine inducing drug-induced liver injury: A case report and systematic review.
Drug Discov Ther. 2025 Jan 14;18(6):325-335. doi: 10.5582/ddt.2024.01087. Epub 2024 Dec 29.
2
Identifying Crude Drugs in Kampo Medicines Associated with Drug-Induced Liver Injury Using the Japanese Adverse Drug Event Report Database: A Comprehensive Survey.利用日本药品不良事件报告数据库识别与药物性肝损伤相关的汉方药中的生药：一项综合调查。
Pharmaceuticals (Basel). 2023 May 1;16(5):678. doi: 10.3390/ph16050678.
3
Adverse Effects of Kampo Medicines.汉方药的副作用。
Intern Med. 2022 Jan 1;61(1):29-35. doi: 10.2169/internalmedicine.6292-20. Epub 2021 Feb 8.
4
Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.黄芩、半枝莲及其商业产品中主要黄酮类成分的比较。
J Nat Med. 2008 Jul;62(3):294-9. doi: 10.1007/s11418-008-0230-7. Epub 2008 Feb 15.
5
Incidence and clinical features of liver injury related to Kampo (Japanese herbal) medicine in 2,496 cases between 1979 and 1999: problems of the lymphocyte transformation test as a diagnostic method.1979年至1999年间2496例与汉方（日本草药） medicine相关的肝损伤的发病率及临床特征：淋巴细胞转化试验作为诊断方法的问题。 注：原文中“Kampo (Japanese herbal) medicine”这里的“medicine”翻译可能不太准确，结合语境推测可能是想说“药物”之类的意思，但仅从这段翻译任务要求出发，按照字面翻译了。整体句子可能存在表述不太清晰准确的情况，或许原文表述上有一定瑕疵。
Phytomedicine. 2002 May;9(4):280-7. doi: 10.1078/0944-7113-00141.