Desai Nihar, Moya Tommy Alfaro, Heffering-Cardwell Michele, Sanchez Felipe Tijmes, Michelis Fotios V, Law Arjun Datt
Hans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.
Temerty Faculty of Medicine University of Toronto Toronto Canada.
EJHaem. 2025 Jul 10;6(4):e70102. doi: 10.1002/jha2.70102. eCollection 2025 Aug.
Granulocyte-colony stimulating factor (G-CSF) is routinely used for peripheral blood stem cells (PBSC) mobilization in healthy donors for allogeneic hematopoietic stem cell transplantation, with mild, transient adverse effects. Pulmonary complications are exceedingly rare in healthy donors. We report a case of acute lung injury in a healthy donor after G-CSF administration requiring hospitalization and treatment with corticosteroids. This case highlights the potential for rare but serious G-CSF-induced pulmonary toxicity, particularly in donors with predisposing factors such as obesity and smoking. Increased awareness of these rare adverse events is essential given the widespread use of G-CSF in PBSC mobilization.
粒细胞集落刺激因子（G-CSF）通常用于动员健康供者的外周血干细胞（PBSC），以进行异基因造血干细胞移植，其不良反应轻微且短暂。肺部并发症在健康供者中极为罕见。我们报告了1例健康供者在使用G-CSF后发生急性肺损伤的病例，该病例需要住院治疗并使用糖皮质激素。该病例凸显了G-CSF诱导的罕见但严重的肺部毒性的可能性，尤其是在有肥胖和吸烟等易感因素的供者中。鉴于G-CSF在PBSC动员中的广泛应用，提高对这些罕见不良事件的认识至关重要。
