Moehlecke Milene, Rheinheimer Jakeline, Crispim Daisy, Trindade Manoel Roberto Maciel, Leitão Cristiane Bauermann
Programa de Graduação em Ciências Médicas: Endocrinologia, Univesidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Arch Endocrinol Metab. 2025 Jul 11;69(3):e240441. doi: 10.20945/2359-4292-2024-0441.
To assess whether plasma irisin is associated with anthropometric, body composition, and metabolic parameters according to body mass index.
A prospective cohort study was conducted at a tertiary referral hospital in Southern Brazil. Patients were divided according to body mass index: Group 1 (body mass index = 18.5 - 29.9 kg/m2; n = 15), Group 2 (body mass index = 30 - 39.9 kg/m2; n = 36), and Group 3 (body mass index ≥ 40 kg/m2; n = 30). Groups 1 and 2 underwent cholecystectomy, while Group 3 underwent Roux-en-Y gastric bypass. All groups were evaluated at baseline, and Groups 2 and 3 were re-evaluated 6 months later. Body composition was assessed using X-ray absorptiometry, and resting energy expenditure was measured by indirect calorimetry.
The study subjects were predominantly female (75%), white (82%), with a mean age of 46 ± 14 years. Group 3 had lower irisin levels compared to Group 2: 9.1 ± 2.2 versus 10.7 ± 2.8 ng/mL; p = 0.038). Irisin was negatively correlated with weight (r = -0.246; p = 0.042), waist circumference (r = -0.272; p = 0.024), glucose (r = -0.259; p = 0.039), glycated hemoglobin (r = -0.283; p = 0.024), triglycerides (r = -0.414; p = 0.024), and positively correlated with HDL (r = 0.280; p = 0.029).
Irisin showed an inverse correlation with insulin-related metabolic pathways, suggesting its potential involvement in insulin resistance states such as obesity and type 2 diabetes.
根据体重指数评估血浆鸢尾素是否与人体测量学、身体成分及代谢参数相关。
在巴西南部一家三级转诊医院进行了一项前瞻性队列研究。患者根据体重指数分组：第1组（体重指数=18.5 - 29.9kg/m²；n = 15），第2组（体重指数=30 - 39.9kg/m²；n = 36），第3组（体重指数≥40kg/m²；n = 30）。第1组和第2组接受胆囊切除术，第3组接受Roux-en-Y胃旁路术。所有组在基线时进行评估，第2组和第3组在6个月后再次评估。使用双能X线吸收法评估身体成分，通过间接测热法测量静息能量消耗。
研究对象以女性为主（75%），白人（82%），平均年龄46±14岁。与第2组相比，第3组鸢尾素水平较低：9.1±2.2对10.7±2.8 ng/mL；p = 0.038）。鸢尾素与体重呈负相关（r = -0.246；p = 0.042），与腰围呈负相关（r = -0.272；p = 0.024），与血糖呈负相关（r = -0.259；p = 0.039），与糖化血红蛋白呈负相关（r = -0.283；p = 0.024），与甘油三酯呈负相关（r = -0.414；p = 0.024），与高密度脂蛋白呈正相关（r = 0.280；p = 0.029）。
鸢尾素与胰岛素相关代谢途径呈负相关，提示其可能参与肥胖和2型糖尿病等胰岛素抵抗状态。
