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Gustilo-Anderson IIIB/C型开放性胫骨骨折的矫形外科治疗:来自中国一级创伤中心的连续10年病例系列研究

Orthoplastic management of Gustilo-Anderson Type IIIB/C open tibial fractures: a consecutive 10-year series from China level I trauma center.

作者信息

Wang Yapeng, Zhou Ming, Wang Peng, Liu Jun, Ma Yunhong, Zhao Gang, Wu Yongwei, Rui Yongjun

机构信息

Soochow University.

Department of Orthoplastic Surgery, Wuxi No.9 People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu Province, China.

出版信息

Int J Surg. 2025 Jul 11;111(9):6135-50. doi: 10.1097/JS9.0000000000002809.

Abstract

BACKGROUND

Research on open tibiofibular fractures is limited. We compared clinical outcomes of Gustilo-Anderson type IIIB/C open tibial fractures using orthopedic and orthoplastic approaches, and identified poor prognosis predictors.

MATERIALS AND METHODS

The clinical data of 746 patients with Gustilo-Anderson type IIIB/C open tibial fractures (420 and 326 treated using the orthopedic and orthoplastic approach, respectively) were retrospectively analyzed. We evaluated infection rates, nonunion incidence, arthritis incidence, number of surgeries, fracture healing time, amputation rate, wound closure duration, and Lower Extremity Functional Scale (LEFS) score, and identified risk factors affecting prognosis.

RESULTS

Significant differences in infection rates (deep infection, 8.0% vs. 29%; superficial infection, 8.0% vs. 41%; all P<0.001), nonunion incidence (11% vs. 2.5%, P<0.001), arthritis incidence (27% vs. 2.1%, P<0.001), number of surgeries (4.6 ± 1.07 vs. 10.7 ± 3.33, P<0.001), and wound coverage time (11.27 ± 5.14 vs. 3.98 ± 1.98, P<0.001) were observed between the groups. LEFS scores from 3 months to 24 months after injury were higher in the orthoplastic group. No difference in fracture healing time was observed (7.0 ± 1.99 vs. 7.0 ± 1.98, P = 0.987). The orthoplastic group required a lower amount of bone graft when using intramedullary nail fixation (6.8 ± 1.42 vs. 19.0 ± 2.88, P<0.001). Smoking (odds ratio [OR], 0.24 for nonunion; 95% confidence interval [CI], 2.29-5.34; P = 0.008 and OR, 0.26 for deep infection; 95% CI, 0.10-0.71; P = 0.009), bone cement block formation (OR, 1.54; 95% CI, 2.06-4.73; P = 0.007), and local antibiotic use (OR, 4.89; 95% CI, 1.93-12.37; P<0.001) were predictors of poor prognosis.

CONCLUSION

The orthoplastic approach offers advantages in the treatment of Gustilo-Anderson type IIIB/C open tibial fractures. Smoking should be avoided, bone cement block molding should be actively adopted, and systemic and local antibiotics should be administered as early as possible. The Flap and Open Reduction Internal Fixation & Masquelet technique reduces the amount of bone graft without increasing deep infection risk.

摘要

背景

关于开放性胫腓骨骨折的研究有限。我们比较了采用骨科和整形手术方法治疗的 Gustilo-Anderson IIIB/C 型开放性胫骨骨折的临床结果,并确定了预后不良的预测因素。

材料与方法

回顾性分析 746 例 Gustilo-Anderson IIIB/C 型开放性胫骨骨折患者的临床资料(分别采用骨科和整形手术方法治疗 420 例和 326 例)。我们评估了感染率、骨不连发生率、关节炎发生率、手术次数、骨折愈合时间、截肢率、伤口闭合持续时间和下肢功能量表(LEFS)评分,并确定了影响预后的危险因素。

结果

两组在感染率(深部感染,8.0% 对 29%;浅表感染,8.0% 对 41%;所有 P<0.001)、骨不连发生率(11% 对 2.5%,P<0.001)、关节炎发生率(27% 对 2.1%,P<0.001)、手术次数(4.6 ± 1.07 对 10.7 ± 3.33,P<0.001)和伤口覆盖时间(11.27 ± 5.14 对 3.98 ± 1.98,P<0.001)方面存在显著差异。整形手术组伤后 3 个月至 24 个月的 LEFS 评分更高。骨折愈合时间无差异(7.0 ± 1.99 对 7.0 ± 1.98,P = 0.987)。整形手术组在使用髓内钉固定时所需的骨移植量较少(6.8 ± 1.42 对 19.0 ± 2.88,P<0.001)。吸烟(骨不连的比值比 [OR],0.24;95% 置信区间 [CI],2.29 - 5.34;P = 0.008,深部感染的 OR,0.26;95% CI,0.10 - 0.71;P = 0.009)、骨水泥块形成(OR,1.54;95% CI,2.06 - 4.73;P = 0.007)和局部使用抗生素(OR,4.89;95% CI,1.93 - 12.37;P<0.001)是预后不良的预测因素。

结论

整形手术方法在治疗 Gustilo-Anderson IIIB/C 型开放性胫骨骨折方面具有优势。应避免吸烟,积极采用骨水泥块塑形,并尽早使用全身和局部抗生素。皮瓣及切开复位内固定与 Masquelet 技术可减少骨移植量且不增加深部感染风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b34b/12430900/37f628122100/js9-111-6135-g001.jpg

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