Blitzer M G, Bailey-Wilson J E, Shapira E
Clin Chim Acta. 1985 Dec 13;153(2):137-42. doi: 10.1016/0009-8981(85)90164-0.
A simple, oral phenylalanine loading test was developed in order to discriminate between controls, phenylketonuria and persistent hyperphenylalaninemia patients. Only three capillary blood specimens for quantitation of phenylalanine and tyrosine over a short duration (90 min) were required. Using stepwise multivariate discriminant analysis, accurate classification was achieved for 27 controls, 12 patients with phenylketonuria and 6 with persistent hyperphenylalaninemia. This loading test and analysis is both simpler and less expensive than those previously described.
为了区分对照组、苯丙酮尿症患者和持续性高苯丙氨酸血症患者，开发了一种简单的口服苯丙氨酸负荷试验。在短时间内（90分钟）仅需采集三份用于定量苯丙氨酸和酪氨酸的毛细血管血标本。通过逐步多元判别分析，对27名对照组、12名苯丙酮尿症患者和6名持续性高苯丙氨酸血症患者实现了准确分类。这种负荷试验和分析比先前描述的方法更简单、成本更低。
