Albertina Emily A, Tomas Carissa W, Geier Timothy J, Timmer-Murillo Sydney C, Pina Isela G, Jazinski-Chambers Kelley, Sauber Garrett, Fitzgerald Jacklynn M, Larson Christine L, deRoon-Cassini Terri A, Hillard Cecilia J
Department of Psychology, University of Wisconsin, Milwaukee, USA.
Medical College of Wisconsin Institute for Health and Equity, Division of Epidemiology and Social Sciences, Milwaukee, USA.
Psychopharmacology (Berl). 2025 Jul 11. doi: 10.1007/s00213-025-06837-4.
Traumatically injured individuals can develop chronic negative psychological sequelae. Improved understanding of contributing, peri-traumatic risk factors is essential to reduce the risk of these consequences. Previous studies have found that peri-traumatic, circulating endocannabinoid concentrations are positively associated with development of post-traumatic stress disorder (PTSD), chronic pain and depression months later, particularly in members of racial/ethnic groups that have been historically marginalized.
This replication study examined relationships among peri-trauma serum endocannabinoid concentrations and long-term consequences in a cohort comprised primarily of individuals from marginalized racial and ethnic groups.
Participants (n = 100; 81% from marginalized racial and ethnic groups) were traumatically injured adults presenting to the ED of an urban tertiary care hospital. Endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) were measured in serum collected within days (peri-trauma) and 6-10 months following injury (follow-up). Assessments, including PTSD, depression, pain and quality of life were completed. Statistical approaches, including multivariate, hierarchical regressions, were used to determine associations among serum endocannabinoid concentrations and long-term outcomes.
Although it did not survive correction for multiple comparisons, peri-trauma serum 2-AG concentrations. Peri-trauma serum 2-AG concentrations were also positively associated with PTSD, pain severity, and functional engagement scores at follow-up. There were no significant associations between circulating 2-AG or AEA and depression.
These findings generally replicate earlier studies demonstrating that serum 2-AG concentrations are biomarkers of risk for PTSD and pain and uncover an additional association with poor functional quality of life. Further studies are needed to determine the underlying mechanisms of these relationships.
创伤性损伤个体可能会出现慢性负面心理后遗症。更好地理解促成创伤的围创伤期风险因素对于降低这些后果的风险至关重要。先前的研究发现，围创伤期循环内源性大麻素浓度与数月后创伤后应激障碍（PTSD）、慢性疼痛和抑郁的发生呈正相关，尤其是在历史上处于边缘地位的种族/族裔群体成员中。
这项重复研究在一个主要由来自边缘化种族和族裔群体的个体组成的队列中，检验了围创伤期血清内源性大麻素浓度与长期后果之间的关系。
参与者（n = 100；81%来自边缘化种族和族裔群体）为在一家城市三级护理医院急诊科就诊的创伤性损伤成年人。在受伤后数天（围创伤期）和6 - 10个月（随访）收集的血清中测量内源性大麻素N - 花生四烯酰乙醇胺（AEA）和2 - 花生四烯酰甘油（2 - AG）。完成包括PTSD、抑郁、疼痛和生活质量在内的评估。采用包括多变量分层回归在内的统计方法来确定血清内源性大麻素浓度与长期结果之间的关联。
尽管在多重比较校正后未通过检验，但围创伤期血清2 - AG浓度。围创伤期血清2 - AG浓度在随访时也与PTSD、疼痛严重程度和功能参与得分呈正相关。循环2 - AG或AEA与抑郁之间无显著关联。
这些发现总体上重复了早期研究，表明血清2 - AG浓度是PTSD和疼痛风险的生物标志物，并揭示了与功能性生活质量差的额外关联。需要进一步研究来确定这些关系的潜在机制。
