Babiker M A, Obeid H A, Ashong E F
Clin Pediatr (Phila). 1985 Dec;24(12):716-8. doi: 10.1177/000992288502401209.
A 6-year-old girl with sickle cell disease was admitted to the hospital with the diagnosis of the acute chest syndrome. The laboratory findings and the radionuclear lung scan supported a diagnosis of pulmonary infarction rather than pneumonia. She improved with intravenous fluids, oxygen, penicillin, and theophylline. The most likely explanation for the rapid resolution of the clinical syndrome, the chest x-ray, and lung scan abnormalities is that masses of sickled cells caused transient pulmonary vascular occlusion leading to perfusion defects and ischemia, and that the sickled cell thrombi were dislodged before the infarction occurred. To our knowledge, this phenomenon has not been described as a cause of the acute chest syndrome in sickle cell disease in children.
一名患有镰状细胞病的6岁女孩因急性胸综合征入院。实验室检查结果和放射性核素肺扫描支持肺梗死而非肺炎的诊断。她通过静脉输液、吸氧、青霉素和茶碱治疗后病情好转。临床综合征、胸部X光片和肺部扫描异常迅速缓解的最可能解释是，镰状细胞团块导致短暂的肺血管阻塞，进而导致灌注缺陷和局部缺血，并且镰状细胞血栓在梗死发生前就已脱落。据我们所知，这种现象尚未被描述为儿童镰状细胞病急性胸综合征的病因。
