Lan Ruihong, Xue Mengdi, Yu Yihong, Huang Xiaoqing, Gong Humin
Department of Obstetrics, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Hainan Medical University, Haikou, Hainan, China.
Clinics (Sao Paulo). 2025 Jul 10;80:100668. doi: 10.1016/j.clinsp.2025.100668.
This work analyzes the effect of the combination of Oxytocin (OXT) combined with cervical balloon dilators on stress injury indicators and inflammatory factors in pregnant women with high-risk pregnancies.
Ninety-three pregnant women with high-risk pregnancies from June 2021 to November 2023 were collected and analyzed retrospectively, of which 43 cases were induced by OXT (control group), and 50 cases were induced by OXT combined with cervical balloon dilators (observation group). The differences in blood pressure and Heart Rate (HR) between the two groups were compared, and the pre-and post-treatment oxidative stress indicators Norepinephrine (NE), Adrenaline (AD), and Cortisol (Cor) and the inflammatory factors Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Prostaglandin E2 (PGE2). In addition, postpartum complications were counted in both groups.
The observation group had higher BP and lower HR than the control group (p < 0.05). After treatment, NE, AD, Cor, TNF-α, IL-1β, IL-6, and PGE2 increased in both groups, but the observation group was lower than the control group (p < 0.05). In addition, there was no difference in the incidence of postpartum complications between the observation group and the control group (p > 0.05).
OXT combined with cervical balloon dilators can effectively ameliorate oxidative stress injury and reduce inflammatory response in high-risk pregnancy women.
本研究分析缩宫素（OXT）联合宫颈球囊扩张器对高危妊娠孕妇应激损伤指标及炎症因子的影响。
回顾性收集2021年6月至2023年11月的93例高危妊娠孕妇，其中43例采用缩宫素引产（对照组），50例采用缩宫素联合宫颈球囊扩张器引产（观察组）。比较两组血压和心率的差异，以及治疗前后氧化应激指标去甲肾上腺素（NE）、肾上腺素（AD）和皮质醇（Cor），和炎症因子肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和前列腺素E2（PGE2）。此外，统计两组产后并发症情况。
观察组血压高于对照组，心率低于对照组（p<0.05）。治疗后，两组NE、AD、Cor、TNF-α、IL-1β、IL-6和PGE2均升高，但观察组低于对照组（p<0.05）。此外，观察组与对照组产后并发症发生率无差异（p>0.05）。
缩宫素联合宫颈球囊扩张器可有效改善高危妊娠孕妇的氧化应激损伤，减轻炎症反应。
