Cuschieri Sarah, Cuschieri Andrea, Ali Shehzad, Stranges Saverio
Faculty of Medicine and Surgery, University of Malta, Msida, Malta; Department of Epidemiology and Biostatistics, Western University, London, Canada.
Faculty of Medicine and Surgery, University of Malta, Msida, Malta.
Nutr Metab Cardiovasc Dis. 2025 Jun 21:104205. doi: 10.1016/j.numecd.2025.104205.
This viewpoint aims to critically examine the growing reliance on pharmacological treatments for obesity and highlight the limitations of such an approach.
Literature from reputable databases and public health registries were sought and used to formulate an evidence-based viewpoint, critically synthesizing current research on obesity pharmacotherapy and its implications within a broader socio-environmental context.
In response to the obesity epidemic, pharmacological treatments have gained significant attention for their ability to produce substantial weight loss in the short-term. However, the increasing reliance on these medication risks narrowing the understanding, prevention and management of obesity to a purely clinical issue, overlooking its deeper individual-level and societal causes. While pharmacological interventions may offer short-term benefits, they do not address the root causes of obesity, such as the socio-environmental drivers influencing food choices with over-reliance on high-calorie and processed foods, sedentary lifestyles, and socio-economic disparities. Additionally, the high cost of these treatments exacerbates health inequities, limiting access for vulnerable populations. Obesity must be approached as a complex, multifaceted condition, requiring multisectoral approaches as well as integrated care models that combine pharmacological treatments with behavioural interventions, lifestyle modifications, and systemic policy changes. Population-wide strategies are crucial for long-term prevention. This viewpoint argues for comprehensive, multisectoral approaches to obesity prevention and management that moves beyond pharmacological solutions to address the broader socio-environmental factors contributing to the obesity epidemic. Only through systemic changes can we expect to improve public health outcomes and reduce the global burden of obesity.
本观点旨在批判性地审视对肥胖症药物治疗的日益依赖,并强调这种方法的局限性。
从知名数据库和公共卫生登记处检索文献,并用于形成基于证据的观点,批判性地综合当前关于肥胖症药物治疗的研究及其在更广泛社会环境背景下的影响。
为应对肥胖症流行,药物治疗因其在短期内能显著减轻体重的能力而备受关注。然而,对这些药物的日益依赖有将肥胖症的理解、预防和管理局限于纯粹临床问题的风险,忽视了其更深层次的个人层面和社会原因。虽然药物干预可能带来短期益处,但它们并未解决肥胖症的根本原因,例如影响食物选择的社会环境驱动因素,过度依赖高热量和加工食品、久坐不动的生活方式以及社会经济差距。此外,这些治疗的高成本加剧了健康不平等,限制了弱势群体的可及性。肥胖症必须被视为一种复杂的、多方面的状况,需要多部门方法以及综合护理模式,将药物治疗与行为干预、生活方式改变和系统性政策变化相结合。全人群策略对于长期预防至关重要。本观点主张采用全面的、多部门方法来预防和管理肥胖症,超越药物解决方案,以解决导致肥胖症流行的更广泛社会环境因素。只有通过系统性变革,我们才能期望改善公共卫生结果并减轻全球肥胖负担。