对新诊断的结直肠癌病例实施普遍微卫星不稳定性检测的务实方法。
Pragmatic approach to implementation of universal MSI testing for new cases of colorectal cancer.
作者信息
Poylin Vitaliy Y, Budlong Austin, Poylin Natasha, Abbas Mohammad
机构信息
Division of Gastrointestinal Surgery, Northwestern Medicine, Northwestern University Feinberg School of Medicine, 676 N. St. Clair St., Suite 650, Chicago, IL, 60611, USA.
Norwest Equity Partners, 250 Nicollet Mall Suite 950, Minneapolis, MN, 55401, USA.
出版信息
Surg Endosc. 2025 Jul 11. doi: 10.1007/s00464-025-11980-2.
BACKGROUND
Microsatellite instability testing is used in cases of colorectal cancer to help identify individuals with Lynch syndrome. There is clinical, but not financial case for this testing. Net Present Value (NPV) is a financial tool designed to calculate whenever investment in the new project is financially sound. We hypothesize that investment into uniform testing on all new colorectal cancers will generate profit over time.
METHODS
Financial model was created based on number of patients seen and tested at tertiary medical center.
RESULTS
Uniform testing will cost $209 per patients (four test at $52.25 per test) and $5,000 is expected to be spent on pathology technician time. In that cohort, 8 out of 200 patients (equal number of males and females) is expected to be identified as having Lynch syndrome. Based on current charges, 5-year NPV is positive at $110,000 and 10-year NPV is positive at $199.663.
CONCLUSIONS
Initial investment into MSI testing on all new cases of colorectal cancer results positive NPV and can help make a case for uniform testing to the hospital.
背景
微卫星不稳定性检测用于结直肠癌病例，以帮助识别林奇综合征患者。这种检测有临床意义，但没有经济方面的理由。净现值（NPV）是一种财务工具，旨在计算对新项目的投资在财务上是否合理。我们假设，对所有新发结直肠癌进行统一检测，随着时间的推移将产生利润。
方法
根据三级医疗中心就诊和检测的患者数量建立财务模型。
结果
统一检测每位患者的成本为209美元（每项检测52.25美元，共四项检测），预计在病理技术员时间上花费5000美元。在该队列中，预计200名患者（男女数量相等）中有8名被确定患有林奇综合征。根据当前收费标准，5年净现值为正，为110,000美元，10年净现值为正，为199,663美元。
结论
对所有新发结直肠癌病例进行微卫星不稳定性检测的初始投资产生了正净现值，并有助于向医院证明统一检测的合理性。
Zotero 插件