Wang Wei, Czader Magdalena, Wang Sa A
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Am J Clin Pathol. 2025 Jul 11;164(1):7-25. doi: 10.1093/ajcp/aqaf009.
This session included 51 cases submitted to the workshop "Progress in T- and NK-cell Lymphomas and Leukemias" by the Society for Hematopathology and European Association for Haematopathology under "Blood/Bone Marrow-Based Mature T- and NK-Cell Leukemias/Lymphomas" or "T/NK-cell neoplasms with a Leukemic Presentation." Entities encompassed T-cell prolymphocytic leukemia, T-cell large granular lymphocytic leukemia (LGLL), natural killer (NK)-LGLL/chronic lymphoproliferative disorder of NK cells, adult T-cell leukemia/lymphoma, aggressive NK-cell leukemia, and their mimics. Submitted cases illustrated classic and variant morphology, immunophenotype, and clinical features; the overlaps with reactive T-cell /NK-cell lymphoproliferations; and challenges in differentiating these entities from other T-cell/NK-cell neoplasms with a leukemic presentation. The cases were assessed using a multidisciplinary approach that included advancements in molecular genetics with their potential impact on clinical practice. We used the most recent classifications and summarized the key points relevant to diagnoses and differential diagnoses of respective entities.
本次会议包含51个病例，这些病例由血液病理学学会和欧洲血液病理学协会提交至“T细胞和NK细胞淋巴瘤及白血病进展”研讨会，主题为“基于血液/骨髓的成熟T细胞和NK细胞白血病/淋巴瘤”或“具有白血病表现的T/NK细胞肿瘤”。涵盖的实体包括T细胞幼淋巴细胞白血病、T细胞大颗粒淋巴细胞白血病（LGLL）、自然杀伤（NK）-LGLL/ NK细胞慢性淋巴细胞增殖性疾病、成人T细胞白血病/淋巴瘤、侵袭性NK细胞白血病及其模仿物。提交的病例展示了典型和变异的形态学、免疫表型及临床特征；与反应性T细胞/NK细胞淋巴增殖的重叠情况；以及将这些实体与其他具有白血病表现的T细胞/NK细胞肿瘤进行鉴别诊断时面临的挑战。采用多学科方法对这些病例进行评估，其中包括分子遗传学进展及其对临床实践的潜在影响。我们使用了最新分类，并总结了与各实体诊断和鉴别诊断相关的关键点。
