Prough D S, Johnson J C, Stullken E H, Stump D A, Poole G V, Howard G
Crit Care Med. 1985 Dec;13(12):1040-4. doi: 10.1097/00003246-198512000-00011.
This study was carried out to determine whether 7.5% hypertonic saline (HSS) and lactated Ringer's solution restore cerebral hemodynamics comparably when used for resuscitation from endotoxic shock. Endotoxic shock was produced in 13 dogs by the iv administration of 1.5 mg/kg Escherichia coli endotoxin. After 90 min of shock, seven animals were resuscitated with lactated Ringer's solution, 60 ml/kg iv, and six with 7.5% HSS, 6 ml/kg iv. Both solutions increased cardiac output and mean arterial pressure. With HSS, intracranial pressure was lower immediately after resuscitation (p less than .001) and one hour later (p less than .01). However, cerebral blood flow was not increased by either fluid and, due to hemodilution, cerebral oxygen transport decreased during resuscitation in both groups of animals. Thus, HSS restored systemic hemodynamics and maintained a lower intracranial pressure during resuscitation from endotoxic shock, but failed, as did lactated Ringer's solution, to restore cerebral blood flow and oxygen transport.
本研究旨在确定7.5%高渗盐水（HSS）和乳酸林格氏液在用于内毒素休克复苏时，恢复脑血流动力学的效果是否相当。通过静脉注射1.5mg/kg大肠杆菌内毒素，在13只犬身上诱导产生内毒素休克。休克90分钟后，7只动物用乳酸林格氏液以60ml/kg静脉注射进行复苏，6只动物用7.5% HSS以6ml/kg静脉注射进行复苏。两种溶液均增加了心输出量和平均动脉压。使用HSS时，复苏后即刻颅内压较低（p<0.001），1小时后也较低（p<0.01）。然而，两种液体均未增加脑血流量，并且由于血液稀释，两组动物在复苏过程中脑氧输送均降低。因此，HSS在从内毒素休克复苏过程中恢复了全身血流动力学并维持了较低的颅内压，但与乳酸林格氏液一样，未能恢复脑血流量和氧输送。
