Kaźmierczak-Barańska Julia, Halczuk Krzysztof, Karwowski Bolesław T
DNA Damage Laboratory, Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.
Nutrients. 2025 Jul 2;17(13):2206. doi: 10.3390/nu17132206.
Thiamine (vitamin B1) is key in maintaining cellular health and energy metabolism. Thiamine is required for proper functioning of enzymes involved in glucose metabolism, which is critical for providing energy to cells. This energy is essential for various cellular processes, including DNA repair mechanisms. In addition, it is a prerequisite for the functioning of key enzymes in the biosynthesis of pentose sugars, which are essential in the synthesis of nucleic acids. Additionally, thiamine has antioxidant properties that help reduce oxidative stress in cells; thus, by relieving this stress, thiamine indirectly supports the maintenance of DNA integrity. Ensuring adequate thiamine intake through diet or supplements can support overall cellular health and potentially aid in DNA repair processes. This review aims to highlight the essential role of vitamin B1 in supporting metabolic health, especially given that deficiencies can develop in patients with disease-related malnutrition as well as in those with an inadequate diet.
硫胺素（维生素B1）对维持细胞健康和能量代谢至关重要。硫胺素是参与葡萄糖代谢的酶正常发挥功能所必需的，而葡萄糖代谢对于为细胞提供能量至关重要。这种能量对于包括DNA修复机制在内的各种细胞过程必不可少。此外，它是戊糖生物合成中关键酶发挥功能的前提条件，而戊糖在核酸合成中至关重要。此外，硫胺素具有抗氧化特性，有助于减少细胞中的氧化应激；因此，通过减轻这种应激，硫胺素间接支持DNA完整性的维持。通过饮食或补充剂确保充足的硫胺素摄入可以支持整体细胞健康，并可能有助于DNA修复过程。本综述旨在强调维生素B1在支持代谢健康方面的重要作用，特别是考虑到疾病相关营养不良患者以及饮食不足者可能会出现缺乏症。
