Skórka Katarzyna, Wdowiak-Filip Anita, Stasiak Grażyna, Bartosińska Joanna, Krasowska Dorota, Giannopoulos Krzysztof
Department of Experimental Hematooncology, Medical University of Lublin, 20-093 Lublin, Poland.
Department of Cosmetology and Aesthetic Medicine, Medical University of Lublin, 20-093 Lublin, Poland.
Cancers (Basel). 2025 Jun 24;17(13):2116. doi: 10.3390/cancers17132116.
Currently, much attention is focused on the interactions between the leukemic and psoriatic cells showing immunosuppressive activity within the microenvironment.
Our study assessed a collective mRNA expression pattern of crucial immuno-regulatory genes: , , , , , , by qRT-PCR, and performed a comparison in two different diseases, chronic lymphocytic leukemia (CLL) and psoriasis (Ps), referring to clinical characteristics.
In Ps, all the studied gene expressions, except , were higher than in HVs and all the studied gene expressions, except , were lower than in CLL. However, the expression of , a checkpoint inhibitor, was higher in 0 stage of CLL and was lower in advanced stages of the disease, suggesting its possible diagnostic value. Expression of was higher in Ps than in HVs, as well as in CLL. It is noteworthy that , and were overexpressed in CLL and Ps compared to HVs, suggesting its involvement in immune suppression in both diseases.
Significant correlations between gene expressions of and , and , and , were observed, indicating a potential shared regulatory mechanism for immune responses which suggests their bidirectional regulatory role on the functioning of immune system cells, depending on the context of inflammatory or neoplastic conditions.
目前，白血病细胞与银屑病细胞之间在微环境中呈现免疫抑制活性的相互作用备受关注。
我们的研究通过qRT-PCR评估了关键免疫调节基因（此处原文缺失具体基因名称）的集体mRNA表达模式，并参照临床特征，在慢性淋巴细胞白血病（CLL）和银屑病（Ps）这两种不同疾病中进行了比较。
在银屑病中，除了（此处原文缺失具体基因名称）外，所有研究的基因表达均高于健康志愿者（HVs），且除了（此处原文缺失具体基因名称）外，所有研究的基因表达均低于慢性淋巴细胞白血病。然而，一种检查点抑制剂（此处原文缺失具体基因名称）的表达在慢性淋巴细胞白血病0期较高，而在疾病晚期较低，提示其可能具有诊断价值。（此处原文缺失具体基因名称）的表达在银屑病中高于健康志愿者，也高于慢性淋巴细胞白血病。值得注意的是，与健康志愿者相比，（此处原文缺失具体基因名称）、（此处原文缺失具体基因名称）和（此处原文缺失具体基因名称）在慢性淋巴细胞白血病和银屑病中均过度表达，表明其参与了两种疾病的免疫抑制。
观察到（此处原文缺失具体基因名称）与（此处原文缺失具体基因名称）、（此处原文缺失具体基因名称）与（此处原文缺失具体基因名称）、（此处原文缺失具体基因名称）与（此处原文缺失具体基因名称）的基因表达之间存在显著相关性，表明免疫反应可能存在共同的调节机制，这表明它们根据炎症或肿瘤状态的背景，对免疫系统细胞的功能具有双向调节作用。
