Zawada E T, Ramirez G
Cutis. 1985 Oct;36(4):341-5, 347.
Fifteen men (average age 54.6 +/- 14.6 years) with IgA-associated glomerulonephritis underwent concomitant skin and renal biopsies to clarify any potential diagnostic relationships. Both types of tissues were studied by standard light, immunofluorescent, and electron microscopic techniques. The glomeruli of all the patients studied showed renal mesangial IgA deposits. All corresponding skin biopsy specimens showed no IgA deposition in the cutaneous blood vessels. The negative association suggests that examination of the skin biopsy specimen alone is not reliable in establishing the diagnosis of primary IgA nephritis. In view of the known skin involvement in Henoch-Schönlein nephropathy, we propose that skin biopsy specimens be examined routinely when renal biopsy specimens demonstrate IgA deposits, to differentiate primary IgA nephropathy from a forme fruste of Henoch-Schönlein purpura.
15名患有IgA相关性肾小球肾炎的男性（平均年龄54.6±14.6岁）接受了同步皮肤和肾脏活检，以明确任何潜在的诊断关系。两种组织均采用标准的光学、免疫荧光和电子显微镜技术进行研究。所有研究患者的肾小球均显示肾系膜IgA沉积。所有相应的皮肤活检标本在皮肤血管中均未显示IgA沉积。这种负相关表明，仅通过检查皮肤活检标本在原发性IgA肾病的诊断中不可靠。鉴于已知皮肤受累于过敏性紫癜性肾炎，我们建议当肾脏活检标本显示IgA沉积时，常规检查皮肤活检标本，以将原发性IgA肾病与过敏性紫癜的顿挫型相鉴别。
