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子宫内膜癌患者生育力保存的循证体重管理:基于医学研究理事会框架制定一项综合干预措施

Evidence-Based Weight Management for Fertility Preservation in Endometrial Cancer Patients: Developing a Complex Intervention Based on the Medical Research Council Framework.

作者信息

Gong Jingjing, Chen Yiqian, Wang Yongli, Gong Yuanyuan, Yang Dandan, Li Xiaodan

机构信息

Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.

Department of Nursing, Beijing Health Vocational College, Beijing 101101, China.

出版信息

Healthcare (Basel). 2025 Jul 7;13(13):1623. doi: 10.3390/healthcare13131623.

DOI:10.3390/healthcare13131623
PMID:40648647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12250016/
Abstract

: This study aims to develop a standardized weight management intervention program for patients with endometrial cancer (EC) undergoing fertility preservation treatment and to provide a scientific foundation for midwives to implement weight management initiatives in the domains of oncology and reproduction. : The weight management intervention program for patients with EC undergoing fertility preservation treatment was crafted following the directives of the Medical Research Council framework for developing and assessing complex interventions and the World Health Organization handbook for guideline development. The development process encompassed four distinct stages: (1) establishing the intervention development group, (2) identifying a theoretical basis and forming a content framework, (3) gathering and synthesizing evidence, and (4) refining and modeling the practice program. : The ultimate weight management program consisted of 6 primary, 18 secondary, and 53 tertiary items. Through two rounds of Delphi consultation, a response rate of 100% was attained, with an expert authority coefficient of 0.83. : The developed intervention demonstrates scientific robustness and clinical feasibility, presenting a structured methodology for weight management for EC patients undergoing fertility preservation therapy.

摘要

本研究旨在为接受生育力保留治疗的子宫内膜癌(EC)患者制定标准化体重管理干预方案,并为助产士在肿瘤学和生殖领域实施体重管理举措提供科学依据。

针对接受生育力保留治疗的EC患者的体重管理干预方案是按照医学研究理事会制定和评估复杂干预措施的框架以及世界卫生组织指南制定手册的指示精心制定的。制定过程包括四个不同阶段:(1)成立干预措施开发小组;(2)确定理论基础并形成内容框架;(3)收集和综合证据;(4)完善并构建实践方案。

最终的体重管理方案包括6项主要项目、18项次要项目和53项第三级项目。通过两轮德尔菲咨询,回复率达到100%,专家权威系数为0.83。

所制定的干预措施具有科学稳健性和临床可行性,为接受生育力保留治疗的EC患者的体重管理提供了一种结构化方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/1b98694f0380/healthcare-13-01623-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/63613fb0af98/healthcare-13-01623-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/a1597daa7586/healthcare-13-01623-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/1b98694f0380/healthcare-13-01623-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/63613fb0af98/healthcare-13-01623-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/a1597daa7586/healthcare-13-01623-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffa/12250016/1b98694f0380/healthcare-13-01623-g003.jpg

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本文引用的文献

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Weight Management for Fertility-Preservation Therapy in Endometrial Cancer: Opportunities and Challenges.子宫内膜癌生育力保护治疗中的体重管理:机遇与挑战
Curr Oncol Rep. 2025 Mar;27(3):195-210. doi: 10.1007/s11912-025-01635-9. Epub 2025 Feb 6.
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A Complex Intervention to Minimize Medication Error by Nurses in Intensive Care: A Case Study.一项旨在减少重症监护病房护士用药错误的综合干预措施:一项案例研究。
Healthcare (Basel). 2025 Jan 2;13(1):66. doi: 10.3390/healthcare13010066.
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Progestin-based pharmacotherapy in fertility preservation in early endometrial cancer.
基于孕激素的药物治疗在早期子宫内膜癌生育力保留中的应用
Front Oncol. 2024 Nov 11;14:1487008. doi: 10.3389/fonc.2024.1487008. eCollection 2024.
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Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据:全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
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Fertility-Sparing Treatment for Endometrial Cancer or Atypical Endometrial Hyperplasia Patients With Obesity.肥胖的子宫内膜癌或非典型子宫内膜增生患者的保留生育功能治疗
Front Oncol. 2022 Feb 18;12:812346. doi: 10.3389/fonc.2022.812346. eCollection 2022.
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Weight Loss During Intrauterine Progestin Treatment for Obesity-associated Atypical Hyperplasia and Early-Stage Cancer of The Endometrium.宫内孕激素治疗肥胖相关非典型增生和子宫内膜早期癌时的体重减轻。
Cancer Prev Res (Phila). 2021 Nov;14(11):1041-1050. doi: 10.1158/1940-6207.CAPR-21-0229. Epub 2021 Aug 4.
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Weight Loss Improves Pregnancy and Livebirth Outcomes in Young Women with Early-Stage Endometrial Cancer and Atypical Hyperplasia.体重减轻可改善早期子宫内膜癌和非典型增生年轻女性的妊娠及活产结局。
Cancer Manag Res. 2021 Jul 14;13:5711-5722. doi: 10.2147/CMAR.S316040. eCollection 2021.
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Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.日本妇科肿瘤学会 2018 年子宫体肿瘤治疗指南。
J Gynecol Oncol. 2020 Jan;31(1):e18. doi: 10.3802/jgo.2020.31.e18. Epub 2019 Oct 17.
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Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.《子宫肿瘤(第 1.2018 版)》,NCCN 肿瘤学临床实践指南。
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