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氧化锌纳米颗粒作为下一代饲料添加剂:连接动物营养中的抗菌功效、生长促进和可持续策略

Zinc Oxide Nanoparticles as Next-Generation Feed Additives: Bridging Antimicrobial Efficacy, Growth Promotion, and Sustainable Strategies in Animal Nutrition.

作者信息

Yang Jiayi, Xiong Dongwei, Long Miao

机构信息

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China.

出版信息

Nanomaterials (Basel). 2025 Jul 2;15(13):1030. doi: 10.3390/nano15131030.

DOI:10.3390/nano15131030
PMID:40648737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12251169/
Abstract

Zinc oxide nanoparticles (ZnO NPs) have attracted significant attention due to their wide-ranging applications in animal production, largely because of their notable biocompatibility, low toxicity, and strong antimicrobial activity. These properties make ZnO NPs a promising substitute for traditional antibiotics. Their application could address the growing concern of antibiotic resistance in livestock industries. This review examines the unique physicochemical characteristics of ZnO NPs, including their nanoscale size and high surface area, which contribute to their biological functionality. Emphasis is placed on green synthesis methods that minimize environmental impact while producing high-quality ZnO NPs. In animal farming, ZnO NPs play a crucial role not only in promoting growth and improving immune responses, but also in enhancing meat and egg quality. Additionally, this review discusses the environmental and safety implications of ZnO NPs, considering their sustainable application potential in future animal production practices, aimed at fostering a more eco-friendly and efficient livestock sector.

摘要

氧化锌纳米颗粒(ZnO NPs)因其在动物生产中的广泛应用而备受关注,这主要归功于其显著的生物相容性、低毒性和强大的抗菌活性。这些特性使ZnO NPs成为传统抗生素的一个有前途的替代品。它们的应用可以解决畜牧业中日益严重的抗生素耐药性问题。本综述探讨了ZnO NPs独特的物理化学特性,包括其纳米级尺寸和高表面积,这些特性有助于其生物学功能。重点介绍了绿色合成方法,这些方法在生产高质量ZnO NPs的同时,最大限度地减少了对环境的影响。在动物养殖中,ZnO NPs不仅在促进生长、改善免疫反应方面发挥着关键作用,而且在提高肉蛋品质方面也发挥着关键作用。此外,本综述还讨论了ZnO NPs对环境和安全的影响,考虑了它们在未来动物生产实践中的可持续应用潜力,旨在促进畜牧业更加环保和高效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/9e7a5084bd66/nanomaterials-15-01030-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/27ff08e8dbe5/nanomaterials-15-01030-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/ec76e20b7576/nanomaterials-15-01030-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/35813ddb9edf/nanomaterials-15-01030-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/9e7a5084bd66/nanomaterials-15-01030-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/27ff08e8dbe5/nanomaterials-15-01030-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/ec76e20b7576/nanomaterials-15-01030-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/35813ddb9edf/nanomaterials-15-01030-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c5a/12251169/9e7a5084bd66/nanomaterials-15-01030-g004.jpg

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本文引用的文献

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Efficacy of zinc nanoparticle supplementation on ruminal environment in lambs.纳米氧化锌对羔羊瘤胃环境的影响。
BMC Vet Res. 2024 Sep 21;20(1):425. doi: 10.1186/s12917-024-04281-8.
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Assessing inorganic nanoparticle toxicity through omics approaches.通过组学方法评估无机纳米颗粒毒性。
Nanoscale. 2024 Aug 29;16(34):15928-15945. doi: 10.1039/d4nr02328e.
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Toxicity of zinc oxide nanoparticles: Cellular and behavioural effects.氧化锌纳米颗粒的毒性:细胞和行为效应。
Chemosphere. 2024 Sep;363:142993. doi: 10.1016/j.chemosphere.2024.142993. Epub 2024 Aug 2.
4
Zinc Oxide Nanoparticles Attenuated Neurochemical and Histopathological Alterations Associated with Aluminium Chloride Intoxication in Rats.氧化锌纳米颗粒减轻了与大鼠氯化铝中毒相关的神经化学和组织病理学改变。
Biol Trace Elem Res. 2025 Apr;203(4):2058-2071. doi: 10.1007/s12011-024-04292-4. Epub 2024 Jul 4.
5
Neuroprotective Effects of Zinc Oxide Nanoparticles in a Rotenone-Induced Mouse Model of Parkinson's Disease.氧化锌纳米粒子在鱼藤酮诱导的帕金森病小鼠模型中的神经保护作用。
Nanotheranostics. 2024 Jun 8;8(4):497-505. doi: 10.7150/ntno.95863. eCollection 2024.
6
Revolutionizing healthcare: Harnessing nano biotechnology with zinc oxide nanoparticles to combat biofilm and bacterial infections-A short review.变革医疗保健:利用纳米生物技术与氧化锌纳米颗粒对抗生物膜和细菌感染——一篇简短综述。
Microb Pathog. 2024 Jun;191:106679. doi: 10.1016/j.micpath.2024.106679. Epub 2024 May 6.
7
Treatment of postpartum endometritis induced by multidrug-resistant bacterial infection in dairy cattle by green synthesized zinc oxide nanoparticles and in vivo evaluation of its broad spectrum antimicrobial activity in cow uteri.奶牛产后多药耐药菌感染性子宫内膜炎的治疗及绿色合成氧化锌纳米粒子在牛子宫内广谱抗菌活性的体内评价。
Res Vet Sci. 2023 Dec;165:105074. doi: 10.1016/j.rvsc.2023.105074. Epub 2023 Nov 2.
8
Zinc oxide and selenium nanoparticles can improve semen quality and heat shock protein expression in cryopreserved goat (Capra hircus) spermatozoa.氧化锌和硒纳米粒子可以提高冷冻保存山羊(Capra hircus)精子的精液质量和热休克蛋白表达。
J Trace Elem Med Biol. 2023 Dec;80:127296. doi: 10.1016/j.jtemb.2023.127296. Epub 2023 Aug 30.
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Effects of Zinc Oxide Nanoparticles Supplementation on Growth Performance, Meat Quality and Serum Biochemical Parameters in Broiler Chicks.纳米氧化锌添加对肉仔鸡生长性能、肉质及血清生化参数的影响
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