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老年人群中直接口服抗凝剂(DOACs)的应用——如何克服老年综合征带来的挑战

The Use of Direct Oral Anticoagulants (DOACs) in the Geriatric Population-How to Overcome the Challenges of Geriatric Syndromes.

作者信息

Badescu Minerva Codruta, Popescu Diana, Gosav Evelina Maria, Costache Alexandru Dan, Cosău Diana Elena, Chetran Adriana, Duca Ștefania-Teodora, Cucută Sandu, Șerban Ionela Lăcrămioara, Costache Enache Irina Iuliana, Rezus Ciprian

机构信息

Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

III Internal Medicine Clinic, "St. Spiridon" County Emergency Clinical Hospital, 700111 Iasi, Romania.

出版信息

J Clin Med. 2025 Jun 20;14(13):4396. doi: 10.3390/jcm14134396.

Abstract

Because the number of elderly people is increasing worldwide, and the prevalence of cardiovascular risk factors and cardiovascular diseases increase with age, in current clinical practice we are faced with a large number of geriatric patients requiring oral anticoagulant treatment. Our review highlights some of the particularities of using direct oral anticoagulants (DOACs) in the geriatric population. We focused on the difficulties of managing DOAC treatment in the presence of geriatric syndromes. We highlighted the practical steps needed to overcome the challenges related to the risk of falling, cognitive impairment, swallowing disorders, and polypragmasy to improve patient care. We provided data to help guide the choice of anticoagulant and dose.

摘要

由于全球老年人口数量不断增加,且心血管危险因素和心血管疾病的患病率随年龄增长而上升,在当前临床实践中,我们面临着大量需要口服抗凝治疗的老年患者。我们的综述强调了在老年人群中使用直接口服抗凝剂(DOACs)的一些特殊性。我们关注了在存在老年综合征的情况下管理DOAC治疗的困难。我们强调了克服与跌倒风险、认知障碍、吞咽障碍和多重用药相关挑战所需的实际步骤,以改善患者护理。我们提供了数据以帮助指导抗凝剂的选择和剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41c5/12250010/5da05ca04295/jcm-14-04396-g001.jpg

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