Tartamus Tita Georgia Valentina, Serban Daniela Elena, Tantau Marcel Vasile
3rd Medical Discipline, Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Mother and Child, 2nd Clinic of Pediatrics, Emergency Clinical Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400177 Cluj-Napoca, Romania.
J Clin Med. 2025 Jun 28;14(13):4597. doi: 10.3390/jcm14134597.
: Pediatric inflammatory bowel disease (pIBD), including Crohn's disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), exhibits unique clinical features compared to adult-onset disease. This study aimed to describe phenotypic characteristics of pIBD in the north-west region of Romania over a 21-year period and to compare our findings with those of other studies worldwide. : We conducted a retrospective study of children under 18 years of age, from the north-west region of Romania, diagnosed with pIBD between 2000 and 2020 at the Emergency Clinical Hospital for Children, Cluj-Napoca. Disease phenotype at diagnosis was established according to the Paris classification. Data were collected from the hospital records and analyzed using descriptive statistics and univariate analysis of categorical variables. A -value < 0.05 was considered statistically significant. : Ninety-four patients were included (CD: 51.0%; UC: 43.6%; IBD-U: 5.4%), with a median age at diagnosis of 14 years (11-15.7). Very early-onset IBD accounted for 5.3% of cases. The likelihood of being diagnosed with CD after 10 years of age was significantly higher compared to UC (OR = 4.75, 95% CI: 1.10-29.07, = 0.03). UC most frequently presented as pancolitis (51.2%), while CD most often involved the ileocolonic region (56.3%). Inflammatory behavior was the most common CD phenotype (69%). Upper gastrointestinal involvement was documented in 18.7% of CD cases, with detection rates increasing after 2014. Perianal disease and growth impairment were significantly associated with complicated CD behavior ( = 0.03, and = 0.007 respectively). Our findings are broadly consistent with other published reports. : This study provides the first detailed phenotypic characterization of pIBD in this region. Our findings reflect trends observed in other populations and underscore the importance of standardized diagnostic evaluation.
小儿炎症性肠病（pIBD），包括克罗恩病（CD）、溃疡性结肠炎（UC）和未分类的IBD（IBD-U），与成人发病的疾病相比具有独特的临床特征。本研究旨在描述罗马尼亚西北地区21年间pIBD的表型特征，并将我们的研究结果与全球其他研究进行比较。
我们对罗马尼亚西北地区18岁以下、2000年至2020年期间在克卢日-纳波卡市儿童急诊临床医院被诊断为pIBD的儿童进行了一项回顾性研究。诊断时的疾病表型根据巴黎分类法确定。数据从医院记录中收集，并使用描述性统计和分类变量的单变量分析进行分析。P值<0.05被认为具有统计学意义。
纳入了94例患者（CD：51.0%；UC：43.6%；IBD-U：5.4%），诊断时的中位年龄为14岁（11-15.7岁）。极早发型IBD占病例的5.3%。10岁后被诊断为CD的可能性显著高于UC（OR=4.75，95%CI：1.10-29.07，P=0.03）。UC最常表现为全结肠炎（51.2%），而CD最常累及回结肠区域（56.3%）。炎症行为是最常见的CD表型（69%）。18.7%的CD病例有上消化道受累，2014年后检出率增加。肛周疾病和生长发育障碍与复杂的CD行为显著相关（分别为P=0.03和P=0.007）。我们的研究结果与其他已发表的报告大致一致。
本研究提供了该地区pIBD首个详细的表型特征描述。我们的研究结果反映了在其他人群中观察到的趋势，并强调了标准化诊断评估的重要性。
