Peypoch Olga, Calsina Juscafresa Laura, Vega-Méndez Antón, Lobato-Delgado Bárbara, Fité Joan, Soto Begoña, Nieto Lluis, de la Rosa Estadella Mireia, Uribezubia Ager, Romero Jose-María, Plana Emma, Miralles Manuel, Clarà Albert, Dilmé Jaume, Soria José Manuel, Camacho Mercedes, Martinez-Perez Angel, Sabater-Lleal Maria
Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.
Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain.
J Clin Med. 2025 Jul 3;14(13):4720. doi: 10.3390/jcm14134720.
The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.
腹主动脉瘤（AAA）破裂风险与动脉瘤大小及生长速率相关。本研究旨在全面描述西班牙人群中AAA直径各区间的生长速率，了解与生长速率变异性相关的可能合并症，并评估医生对AAA患者进行安全随访的情况。我们介绍了巴塞罗那AAA研究（TABS），这是一项新的基于医院的纵向研究，在巴塞罗那招募连续的AAA患者。到目前为止，已招募了469名测量了腹主动脉直径的个体，以及大多数随访时的人体测量、临床信息和血液样本。使用线性混合效应模型进行统计建模，以确定AAA患者中直径大小和扩张的最相关预测因素。初始直径在30至40毫米之间的动脉瘤，每个区间的平均生长速率为0.78（2.34）毫米/年；初始直径在40至50毫米之间的动脉瘤，为1.22（3.34）毫米/年；初始直径等于或大于50毫米的动脉瘤，为4.12（5.09）毫米/年。决定主动脉直径以外生长速率的主要因素是性别和相关合并症（慢性阻塞性肺疾病和糖尿病）。小动脉瘤患者达到手术阈值的估计时间平均超过10年。总体而言，本研究是朝着开发更好的预测工具迈出的有希望的一步，以评估西班牙人群中AAA患者的临床决策并指导未来的筛查政策。
