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无催化剂自发氮杂曼尼希/内酰胺化串联反应：便捷合成多环δ-内酰胺

Catalyst-Free Spontaneous Aza-Mannich/Lactamization Cascade Reaction: Easy Access to Polycyclic δ-Lactams.

作者信息

Di Mola Antonia, Vietri Caterina, Tedesco Consiglia, Massa Antonio

机构信息

Dipartimento di Chimica e Biologia "A. Zambelli", Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.

出版信息

Molecules. 2025 Jun 23;30(13):2702. doi: 10.3390/molecules30132702.

DOI:10.3390/molecules30132702
PMID:40649220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12251525/
Abstract

Ring-fused azacyclic compounds are important building blocks in the synthesis of natural products and pharmaceutical agents. Herein, we report an effective and valuable one-pot approach to obtaining polycyclic fused δ-lactams from readily available 2-formylphenyl acetate and diamines under catalyst-free and green conditions.

摘要

稠环氮杂环化合物是天然产物和药物合成中的重要结构单元。在此，我们报道了一种有效且有价值的一锅法，可在无催化剂和绿色条件下，由易得的乙酸2-甲酰基苯酯和二胺制备多环稠合δ-内酰胺。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/f68b8fc587cb/molecules-30-02702-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/7f6e5c8bcb96/molecules-30-02702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/3cc0af461020/molecules-30-02702-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/5bb947af8fc7/molecules-30-02702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/be420cf4eae8/molecules-30-02702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/2096ae9af858/molecules-30-02702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/8ca4e2cbecae/molecules-30-02702-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/7b0e9fc05222/molecules-30-02702-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/f68b8fc587cb/molecules-30-02702-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/7f6e5c8bcb96/molecules-30-02702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/3cc0af461020/molecules-30-02702-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/5bb947af8fc7/molecules-30-02702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/be420cf4eae8/molecules-30-02702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/2096ae9af858/molecules-30-02702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/8ca4e2cbecae/molecules-30-02702-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/7b0e9fc05222/molecules-30-02702-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8838/12251525/f68b8fc587cb/molecules-30-02702-sch003.jpg

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本文引用的文献

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在无催化剂条件下，通过曼尼希反应或Sn2引发的级联反应可轻松合成1-取代和未取代的3-异喹啉酮。
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