Prechtel K, Geiger G
Dtsch Med Wochenschr. 1985 Dec 6;110(49):1883-8. doi: 10.1055/s-2008-1069107.
Out of a total of 1306 women (average age 42 years) with a biopsy proven mastopathy, manifest ipsilateral carcinoma occurred in 13 during the following 6 years. Thus the incidence of carcinoma differed little from the expected number of new cases in women of a comparable age. However, subdivision of breast lesions into simple (n = 1052) and proliferative (n = 254) forms showed that the carcinoma risk is double in proliferative mastopathy and fourfold higher when mastopathy with atypical epithelial proliferation is considered. An association with contraceptive hormones was not seen.
在总计1306名经活检证实患有乳腺病的女性（平均年龄42岁）中，有13名在接下来的6年中出现了同侧明显癌变。因此，癌变发生率与年龄相仿女性中新发病例的预期数量相差不大。然而，将乳腺病变细分为单纯性（n = 1052）和增生性（n = 254）两种类型后发现，增生性乳腺病患者患癌风险加倍，若考虑伴有非典型上皮增生的乳腺病，其患癌风险则高出四倍。未发现与避孕激素有关联。
