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聚乳酸与聚醚砜及铜络合磷酸纤维素复合材料的制备及其生化和微生物行为

Preparation and Biochemical and Microbial Behavior of Poly(Lactide) Composites with Polyethersulfone and Copper-Complexed Cellulose Phosphate.

作者信息

Kudzin Marcin H, Mrozińska Zdzisława, Kaczmarek Anna, Chruściel Jerzy J, Gloc Martyna, Żyłła Renata

机构信息

Łukasiewicz Research Network-Lodz Institute of Technology, 19/27 Marii Sklodowskiej-Curie Street, 90-570 Lodz, Poland.

Department of Bioprocess Engineering, Faculty of Process and Environmental Engineering, Lodz Univeristy of Technology, 213 Wolczanska Street, 90-924 Lodz, Poland.

出版信息

Materials (Basel). 2025 Jun 22;18(13):2954. doi: 10.3390/ma18132954.

DOI:10.3390/ma18132954
PMID:40649442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12250920/
Abstract

This research investigates the biochemical and microbiological characteristics of a composite comprising poly(lactide) (PLA) combined with polyethersulfone (PESf) and copper-complexed cellulose phosphate (CelP-Cu). The material was produced using the pneumothermic melt-blown method and then modified with polyethersulfone and cellulose phosphate, followed by complexation with copper ions using the dip-coating technique. Comprehensive physicochemical and biological evaluations were conducted to characterize the composite. The physicochemical assessments involved elemental analysis (C, O, Cu) and morphology examination. The biological evaluations encompassed microbiological testing and biochemical-hematological analysis, including activated partial thromboplastin time (aPTT) and prothrombin time (PT). Antimicrobial activity was assessed according to the EN ISO 20645:2006 and EN 14119:2005 standards, by placing material specimens on agar plates inoculated with representative microorganisms. The results revealed that the composites exhibited significant antimicrobial effects against model microorganisms: , , , , , , , , . This study highlights the potential of PLA/PESf/CelP-Cu composites for novel biomedical applications, demonstrating their biocompatibility and their influence on hemostatic processes and antimicrobial properties.

摘要

本研究调查了一种由聚乳酸（PLA）与聚醚砜（PESf）以及铜络合纤维素磷酸盐（CelP-Cu）组成的复合材料的生化和微生物特性。该材料采用气动热熔喷吹法制备，然后用聚醚砜和纤维素磷酸盐进行改性，接着使用浸涂技术与铜离子进行络合。进行了全面的物理化学和生物学评估以表征该复合材料。物理化学评估包括元素分析（C、O、Cu）和形态学检查。生物学评估包括微生物测试和生化血液学分析，其中包括活化部分凝血活酶时间（aPTT）和凝血酶原时间（PT）。根据EN ISO 20645:2006和EN 14119:2005标准，通过将材料样本放置在接种有代表性微生物的琼脂平板上来评估抗菌活性。结果表明，该复合材料对模型微生物： ， ， ， ， ， ， ， 表现出显著的抗菌效果。本研究突出了PLA/PESf/CelP-Cu复合材料在新型生物医学应用方面的潜力，证明了它们的生物相容性以及它们对止血过程和抗菌性能的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/9e054dc216a8/materials-18-02954-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/3535b075d96a/materials-18-02954-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/663ac0019782/materials-18-02954-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/89d78900566d/materials-18-02954-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/2f833d1fbe14/materials-18-02954-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/dd898b8a1ecf/materials-18-02954-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/796b5b697766/materials-18-02954-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/b41598d40d16/materials-18-02954-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/2e0b30e38e2c/materials-18-02954-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/9e054dc216a8/materials-18-02954-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/3535b075d96a/materials-18-02954-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/663ac0019782/materials-18-02954-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/89d78900566d/materials-18-02954-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/2f833d1fbe14/materials-18-02954-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/dd898b8a1ecf/materials-18-02954-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/796b5b697766/materials-18-02954-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/b41598d40d16/materials-18-02954-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/2e0b30e38e2c/materials-18-02954-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ded/12250920/9e054dc216a8/materials-18-02954-g009.jpg

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本文引用的文献

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Int J Mol Sci. 2024 Apr 11;25(8):4233. doi: 10.3390/ijms25084233.
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Applications of PLA in modern medicine.聚乳酸在现代医学中的应用。
Eng Regen. 2020;1:76-87. doi: 10.1016/j.engreg.2020.08.002. Epub 2020 Sep 6.
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Biochemical Approach to Poly(Lactide)-Copper Composite-Impact on Blood Coagulation Processes.聚乳酸-铜复合材料的生化研究方法——对血液凝固过程的影响
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Blood Coagulation Activities of Cotton-Alginate-Copper Composites.棉-海藻酸钠-铜复合材料的凝血活性。
Mar Drugs. 2023 Nov 30;21(12):625. doi: 10.3390/md21120625.
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Toxicity Mechanisms of Copper Nanoparticles and Copper Surfaces on Bacterial Cells and Viruses.铜纳米颗粒和铜表面对细菌细胞和病毒的毒性机制。
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