Borzyszkowska Dominika, Kozłowski Mateusz, Golara Anna, Piotrowska Katarzyna, Brodowska Agnieszka, Brodowski Jacek, Bojar Iwona, Kempinska-Podhorodecka Agnieszka, Cymbaluk-Płoska Aneta
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Department of Physiology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Int J Mol Sci. 2025 Jun 22;26(13):5996. doi: 10.3390/ijms26135996.
One of the most prevalent types of cancer among women is ovarian cancer. The search for ovarian cancer markers is constantly ongoing. Evaluation of LAG-3 and TIM-3 protein expression in ovarian cancer tissue and its role in distinguishing the clinical signs stated were the objectives of this study. Methods: A total of 58 ovarian cancer patients were recruited for this study. The cohort was split into two groups: one for high-grade serous ovarian cancer (HGSOC) and another for ovarian cancer that was not HGSOC (non-HGSOC). LAG-3 and TIM-3 protein expression in ovarian cancer tissue samples was evaluated by immunohistochemistry. StatView 5.0 software (Carry, NC, USA) was used for all statistical analyses. Both LAG-3 and TIM-3 proteins mostly showed positive, moderately positive, or strongly positive expression. This study shows that LAG-3 could be a marker associated with BMI in the non-HGSOC group. TIM-3 may be a marker associated with age in a group of all ovarian cancers. LAG-3 expression is associated with TIM-3 expression in the total cohort and the HGSOC and non-HGSOC groups.
卵巢癌是女性中最常见的癌症类型之一。对卵巢癌标志物的研究一直在进行。本研究的目的是评估卵巢癌组织中LAG-3和TIM-3蛋白的表达及其在区分所述临床体征中的作用。方法：本研究共招募了58名卵巢癌患者。该队列分为两组：一组为高级别浆液性卵巢癌（HGSOC），另一组为非高级别浆液性卵巢癌（非HGSOC）。通过免疫组织化学评估卵巢癌组织样本中LAG-3和TIM-3蛋白的表达。所有统计分析均使用StatView 5.0软件（美国北卡罗来纳州卡里）。LAG-3和TIM-3蛋白大多呈阳性、中度阳性或强阳性表达。本研究表明，在非HGSOC组中，LAG-3可能是与BMI相关的标志物。在所有卵巢癌组中，TIM-3可能是与年龄相关的标志物。在整个队列以及HGSOC和非HGSOC组中，LAG-3表达与TIM-3表达相关。
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