Sárik Julián Robin, Szatmári István, Lőrinczi Bálint
Institute of Pharmaceutical Chemistry, University of Szeged, Eotvos u. 6, H-6720 Szeged, Hungary.
HUN-REN SZTE Stereochemistry Research Group, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Int J Mol Sci. 2025 Jun 28;26(13):6248. doi: 10.3390/ijms26136248.
Kynurenic acid (KYNA) derivatives condensed with an aromatic ring (tricyclic KYNA derivatives) have been successfully synthesized, and the reactivity of these analogues has been investigated in the modified Mannich reaction resulting in new Mannich bases. The -dimethyl-ethylenediamine analogues of the tricyclic KYNA derivatives have also been successfully synthesized, and their reactivity in the modified Mannich reaction was investigated. The synthesized ring systems bear resemblance to molecules previously investigated as G-quadruplex binding agents. Based on this similarity, the synthesized tricyclic KYNA derivatives could be investigated as potential antiviral and anticancer molecules.
已成功合成了与芳香环缩合的犬尿喹啉酸（KYNA）衍生物（三环KYNA衍生物），并在改良的曼尼希反应中研究了这些类似物的反应活性，从而得到了新的曼尼希碱。三环KYNA衍生物的-N，N-二甲基乙二胺类似物也已成功合成，并研究了它们在改良曼尼希反应中的反应活性。合成的环系与先前作为G-四链体结合剂研究的分子相似。基于这种相似性，可以将合成的三环KYNA衍生物作为潜在的抗病毒和抗癌分子进行研究。
